Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون:	Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
مؤلفون آخرون:	School of Biological Sciences
التنسيق:	Journal Article
اللغة:	English
منشور في:	2016
الموضوعات:	Eukaryotic initiation factor glutamic acid
الوصول للمادة أونلاين:	https://hdl.handle.net/10356/81961 http://hdl.handle.net/10220/41065

الانترنت

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

الانترنت

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