Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

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Detalhes bibliográficos
Main Authors: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Outros Autores: School of Biological Sciences
Formato: Journal Article
Idioma:English
Publicado em: 2016
Assuntos:
Eukaryotic initiation factor
glutamic acid
Acesso em linha:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

Internet

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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