Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

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Main Authors: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
其他作者: School of Biological Sciences
格式: Journal Article
语言:English
出版: 2016
主题:
Eukaryotic initiation factor
glutamic acid
在线阅读:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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