Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

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Bibliográfalaš dieđut
Váldodahkkit: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Eará dahkkit: School of Biological Sciences
Materiálatiipa: Journal Article
Giella:English
Almmustuhtton: 2016
Fáttát:
Eukaryotic initiation factor
glutamic acid
Liŋkkat:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

Interneahtta

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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