Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

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Dades bibliogràfiques
Autors principals: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Altres autors: School of Biological Sciences
Format: Journal Article
Idioma:English
Publicat: 2016
Matèries:
Eukaryotic initiation factor
glutamic acid
Accés en línia:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

Internet

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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