Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

Πλήρης περιγραφή

Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
Άλλοι συγγραφείς: School of Biological Sciences
Μορφή: Journal Article
Γλώσσα:English
Έκδοση: 2016
Θέματα:
Διαθέσιμο Online:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065