Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Probing the Binding Mechanism of Mnk Inhibitors by Docking and Molecular Dynamics Simulations

Mitogen-activated protein kinases-interacting kinase 1 and 2 (Mnk1/2) activate the oncogene eukaryotic initiation factor 4E (eIF4E) by phosphorylation. High level of phosphorylated eIF4E is associated with various types of cancers. Inhibition of Mnk prevents eIF4E phosphorylation, making them potent...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों: Kannan, Srinivasaraghavan, Poulsen, Anders, Yang, Hai Yan, Ho, Melvyn, Ang, Shi Hua, Eldwin, Tan Sum Wai, Jeyaraj, Duraiswamy Athisayamani, Chennamaneni, Lohitha Rao, Liu, Boping, Hill, Jeffrey, Verma, Chandra Shekhar, Nacro, Kassoum
अन्य लेखक: School of Biological Sciences
स्वरूप: Journal Article
भाषा:English
प्रकाशित: 2016
विषय:
Eukaryotic initiation factor
glutamic acid
ऑनलाइन पहुंच:https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

इंटरनेट

https://hdl.handle.net/10356/81961
http://hdl.handle.net/10220/41065

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