Optogenetic Visualization of Presynaptic Tonic Inhibition of Cerebellar Parallel Fibers
Tonic inhibition was imaged in cerebellar granule cells of transgenic mice expressing the optogenetic chloride indicator, Clomeleon. Blockade of GABAA receptors substantially reduced chloride concentration in granule cells due to block of tonic inhibition. This indicates that tonic inhibition is a s...
Main Authors: | Berglund, Ken, Wen, Lei, Dunbar, Robert L., Feng, Guoping, Augustine, George James |
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Other Authors: | Lee Kong Chian School of Medicine (LKCMedicine) |
Format: | Journal Article |
Language: | English |
Published: |
2016
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Subjects: | |
Online Access: | https://hdl.handle.net/10356/81981 http://hdl.handle.net/10220/41039 |
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