Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases
Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/81982 http://hdl.handle.net/10220/41532 |
| _version_ | 1826116392721580032 |
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| author | Eklund, Yvonne Aronsson, Annika Schmidtchen, Artur Relander, Thomas |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Eklund, Yvonne Aronsson, Annika Schmidtchen, Artur Relander, Thomas |
| author_sort | Eklund, Yvonne |
| collection | NTU |
| description | Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Forty-four patients with clinically and histopathologically verified MF were identified during the period, with a mean follow-up time of 5.6 years. Median age at initial diagnosis was 64 years. In several cases other skin diseases preceded MF onset, such as non-specific dermatitis (32%) and parapsoriasis (30%). The majority of patients (86%, n = 38) had limited-stage (IA–IB) disease at the time of diagnosis. Overall response rate to psoralen plus ultraviolet A (PUVA) treatment was 81%. In adnexal MF, a trend to higher rate of progression to an advanced stage was observed when compared with non-adnexal disease (40% and 21%, respectively). Increased levels of soluble interleukin-2 (IL-2) receptor correlated with disease stage, being elevated in advanced stages or adnexal disease, but almost never elevated in early non-adnexal limited-stage disease. Overall mortality was 25%, but only 11% could be verified as caused by MF. |
| first_indexed | 2024-10-01T04:10:58Z |
| format | Journal Article |
| id | ntu-10356/81982 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:10:58Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/819822020-11-01T05:16:40Z Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases Eklund, Yvonne Aronsson, Annika Schmidtchen, Artur Relander, Thomas Lee Kong Chian School of Medicine (LKCMedicine) mycosis fungoides cutaneous T-cell lymphoma Mycosis fungoides (MF) is a primary cutaneous T-cell lymphoma with slow disease progression. There is a lack of descriptive data from Sweden concerning patients with this diagnosis. This study extracted data on patients admitted to the dermatology department at Lund University Hospital, Sweden from 1996 to 2010. Forty-four patients with clinically and histopathologically verified MF were identified during the period, with a mean follow-up time of 5.6 years. Median age at initial diagnosis was 64 years. In several cases other skin diseases preceded MF onset, such as non-specific dermatitis (32%) and parapsoriasis (30%). The majority of patients (86%, n = 38) had limited-stage (IA–IB) disease at the time of diagnosis. Overall response rate to psoralen plus ultraviolet A (PUVA) treatment was 81%. In adnexal MF, a trend to higher rate of progression to an advanced stage was observed when compared with non-adnexal disease (40% and 21%, respectively). Increased levels of soluble interleukin-2 (IL-2) receptor correlated with disease stage, being elevated in advanced stages or adnexal disease, but almost never elevated in early non-adnexal limited-stage disease. Overall mortality was 25%, but only 11% could be verified as caused by MF. Published version 2016-10-03T06:56:59Z 2019-12-06T14:44:12Z 2016-10-03T06:56:59Z 2019-12-06T14:44:12Z 2016 Journal Article Eklund, Y., Aronsson, A., Schmidtchen, A., & Relander, T. (2016). Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases. Acta Dermato Venereologica, 96, 669-673. 0001-5555 https://hdl.handle.net/10356/81982 http://hdl.handle.net/10220/41532 10.2340/00015555-2337 en Acta Dermato Venereologica © 2016 The Authors. This paper was published in Acta Dermato Venereologica and is made available as an electronic reprint (preprint) with permission of Acta Dermato Venereologica. The published version is available at: [http://dx.doi.org/10.2340/00015555-2337]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 6 p. application/pdf |
| spellingShingle | mycosis fungoides cutaneous T-cell lymphoma Eklund, Yvonne Aronsson, Annika Schmidtchen, Artur Relander, Thomas Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases |
| title | Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases |
| title_full | Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases |
| title_fullStr | Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases |
| title_full_unstemmed | Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases |
| title_short | Mycosis Fungoides: A Retrospective Study of 44 Swedish Cases |
| title_sort | mycosis fungoides a retrospective study of 44 swedish cases |
| topic | mycosis fungoides cutaneous T-cell lymphoma |
| url | https://hdl.handle.net/10356/81982 http://hdl.handle.net/10220/41532 |
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