Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres
Topical skin and nail fungal infections form the most numerous and widespread among superficial mycoses. Drug eluting electrospun nanofibres have been shown to have immense potential for the topical delivery of antimicrobials. In this article, we investigated the efficacy of lecithin-loaded electros...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/81984 http://hdl.handle.net/10220/41035 |
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| author | Harini, Sriram Venkatesh, Mayandi Radhakrishnan, Sridhar Fazil, Mobashar Hussain Urf Turabe Goh, Eunice Tze Leng Rui, Sun Dhand, Chetna Ong, Seow Theng Barathi, Veluchamy Amutha Beuerman, Roger W. Ramakrishna, Seeram Verma, Navin Kumar Lakshminarayanan, Rajamani |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Harini, Sriram Venkatesh, Mayandi Radhakrishnan, Sridhar Fazil, Mobashar Hussain Urf Turabe Goh, Eunice Tze Leng Rui, Sun Dhand, Chetna Ong, Seow Theng Barathi, Veluchamy Amutha Beuerman, Roger W. Ramakrishna, Seeram Verma, Navin Kumar Lakshminarayanan, Rajamani |
| author_sort | Harini, Sriram |
| collection | NTU |
| description | Topical skin and nail fungal infections form the most numerous and widespread among superficial mycoses. Drug eluting electrospun nanofibres have been shown to have immense potential for the topical delivery of antimicrobials. In this article, we investigated the efficacy of lecithin-loaded electrospun polycaprolactone (PCL) fibers containing terbinafine hydrochloride (terbinafine) for applications in superficial mycoses. Electron microscopy studies indicated that addition of lecithin and terbinafine decreased the average diameter of PCL nanofibers, increase in mechanical properties and wettability of the fibre mats. PCL mats containing lecithin and terbinafine displayed pronounced blue photoluminescence and did not affect cell adhesion and biocompatibility for primary human dermal fibroblasts. The drug loaded mats maintained the antifungal efficacy against moulds as well as dermatophytic fungus. Using an ex vivo porcine skin infection model, we showed that the drug-eluting mats resulted in >5 log reduction in the viability of T. mentagrophytes. |
| first_indexed | 2024-10-01T04:38:14Z |
| format | Journal Article |
| id | ntu-10356/81984 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:38:14Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/819842020-11-01T05:18:29Z Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres Harini, Sriram Venkatesh, Mayandi Radhakrishnan, Sridhar Fazil, Mobashar Hussain Urf Turabe Goh, Eunice Tze Leng Rui, Sun Dhand, Chetna Ong, Seow Theng Barathi, Veluchamy Amutha Beuerman, Roger W. Ramakrishna, Seeram Verma, Navin Kumar Lakshminarayanan, Rajamani Lee Kong Chian School of Medicine (LKCMedicine) Electrospinning Nanofibres Topical skin and nail fungal infections form the most numerous and widespread among superficial mycoses. Drug eluting electrospun nanofibres have been shown to have immense potential for the topical delivery of antimicrobials. In this article, we investigated the efficacy of lecithin-loaded electrospun polycaprolactone (PCL) fibers containing terbinafine hydrochloride (terbinafine) for applications in superficial mycoses. Electron microscopy studies indicated that addition of lecithin and terbinafine decreased the average diameter of PCL nanofibers, increase in mechanical properties and wettability of the fibre mats. PCL mats containing lecithin and terbinafine displayed pronounced blue photoluminescence and did not affect cell adhesion and biocompatibility for primary human dermal fibroblasts. The drug loaded mats maintained the antifungal efficacy against moulds as well as dermatophytic fungus. Using an ex vivo porcine skin infection model, we showed that the drug-eluting mats resulted in >5 log reduction in the viability of T. mentagrophytes. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version 2016-08-02T04:26:35Z 2019-12-06T14:44:15Z 2016-08-02T04:26:35Z 2019-12-06T14:44:15Z 2016 Journal Article Harini, S., Venkatesh, M., Radhakrishnan, S., Fazil, M. H. U. T., Goh, E. T. L., Rui, S., et al. (2016). Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres. RSC Advances, 6(47), 41130-41141. https://hdl.handle.net/10356/81984 http://hdl.handle.net/10220/41035 10.1039/C6RA04755F en RSC Advances © 2016 The Royal Society of Chemistry. This is the author created version of a work that has been peer reviewed and accepted for publication by RSC Advances, The Royal Society of Chemistry. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C6RA04755F]. 33 p. application/pdf |
| spellingShingle | Electrospinning Nanofibres Harini, Sriram Venkatesh, Mayandi Radhakrishnan, Sridhar Fazil, Mobashar Hussain Urf Turabe Goh, Eunice Tze Leng Rui, Sun Dhand, Chetna Ong, Seow Theng Barathi, Veluchamy Amutha Beuerman, Roger W. Ramakrishna, Seeram Verma, Navin Kumar Lakshminarayanan, Rajamani Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres |
| title | Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres |
| title_full | Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres |
| title_fullStr | Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres |
| title_full_unstemmed | Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres |
| title_short | Antifungal properties of lecithin- and terbinafine-loaded electrospun poly(ε-caprolactone) nanofibres |
| title_sort | antifungal properties of lecithin and terbinafine loaded electrospun poly ε caprolactone nanofibres |
| topic | Electrospinning Nanofibres |
| url | https://hdl.handle.net/10356/81984 http://hdl.handle.net/10220/41035 |
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