Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

Structure of the Varicella Zoster Virus Thymidylate Synthase Establishes Functional and Structural Similarities as the Human Enzyme and Potentiates Itself as a Target of Brivudine

Varicella zoster virus (VZV) is a highly infectious human herpesvirus that is the causative agent for chicken pox and shingles. VZV encodes a functional thymidylate synthase (TS), which is the sole enzyme that produces dTMP from dUMP de novo. To study substrate binding, the complex structure of TSVZ...

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Bibliographic Details
Main Authors: Hew, Kelly, Dahlroth, Sue-Li, Veerappan, Saranya, Pan, Lucy Xin, Cornvik, Tobias, Nordlund, Pär
Other Authors: Roujeinikova, Anna
Format: Journal Article
Language:English
Published: 2016
Subjects:
fluorometry
drug targeting
Online Access:https://hdl.handle.net/10356/82348
http://hdl.handle.net/10220/39978

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