Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree of severity, and also have a high risk of early Alzheimer's disease (AD). ID prior to the onset of dementia, and its relationship to the onset of dementia in DS is a complex phenomenon influenced...

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Bibliographic Details
Main Authors: Nizetic, Dean, Chen, Christopher L., Hong, Wanjin, Koo, Edward H.
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2016
Subjects:
Down syndrome
Vascular dementia
Neuron activity-dependent
Cognitive dysfunction
Amyloid beta-peptides
Amyloid beta-protein precursor
Online Access:https://hdl.handle.net/10356/82597
http://hdl.handle.net/10220/40342

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