Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents
We report the first study of highly monodisperse and crystalline iron oxide nanocubes with sub-nm controlled size distribution (9.7 ± 0.5 nm in size) that achieve simultaneous contrast enhancement in both T1- and T2-weighted magnetic resonance imaging (MRI). Here, we confirmed the magnetite structur...
| Main Authors: | , , , , |
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| Format: | Journal Article |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/82700 http://hdl.handle.net/10220/40290 |
| _version_ | 1811690906007371776 |
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| author | Sharma, Vijay Kumar Alipour, A. Soran-Erdem, Z. Aykut, Z. G. Demir, Hilmi Volkan |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Sharma, Vijay Kumar Alipour, A. Soran-Erdem, Z. Aykut, Z. G. Demir, Hilmi Volkan |
| author_sort | Sharma, Vijay Kumar |
| collection | NTU |
| description | We report the first study of highly monodisperse and crystalline iron oxide nanocubes with sub-nm controlled size distribution (9.7 ± 0.5 nm in size) that achieve simultaneous contrast enhancement in both T1- and T2-weighted magnetic resonance imaging (MRI). Here, we confirmed the magnetite structure of iron oxide nanocubes by X-ray diffraction (XRD), selected area electron diffraction (SAED) pattern, optical absorption and Fourier transformed infrared (FT-IR) spectra. These magnetite nanocubes exhibit superparamagnetic and paramagnetic behavior simultaneously by virtue of their finely controlled shape and size. The magnetic measurements reveal that the magnetic moment values are favorably much lower because of the small size and cubic shape of the nanoparticles, which results in an enhanced spin canting effect. As a proof-of-concept demonstration, we showed their potential as dual contrast agents for both T1- and T2-weighted MRI via phantom studies, in vivo imaging and relaxivity measurements. Therefore, these low-magnetization magnetite nanocubes, while being non-toxic and bio-compatible, hold great promise as excellent dual-mode T1 and T2 contrast agents for MRI. |
| first_indexed | 2024-10-01T06:11:26Z |
| format | Journal Article |
| id | ntu-10356/82700 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:11:26Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/827002023-02-28T19:29:19Z Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents Sharma, Vijay Kumar Alipour, A. Soran-Erdem, Z. Aykut, Z. G. Demir, Hilmi Volkan School of Electrical and Electronic Engineering School of Physical and Mathematical Sciences Nanotechnology We report the first study of highly monodisperse and crystalline iron oxide nanocubes with sub-nm controlled size distribution (9.7 ± 0.5 nm in size) that achieve simultaneous contrast enhancement in both T1- and T2-weighted magnetic resonance imaging (MRI). Here, we confirmed the magnetite structure of iron oxide nanocubes by X-ray diffraction (XRD), selected area electron diffraction (SAED) pattern, optical absorption and Fourier transformed infrared (FT-IR) spectra. These magnetite nanocubes exhibit superparamagnetic and paramagnetic behavior simultaneously by virtue of their finely controlled shape and size. The magnetic measurements reveal that the magnetic moment values are favorably much lower because of the small size and cubic shape of the nanoparticles, which results in an enhanced spin canting effect. As a proof-of-concept demonstration, we showed their potential as dual contrast agents for both T1- and T2-weighted MRI via phantom studies, in vivo imaging and relaxivity measurements. Therefore, these low-magnetization magnetite nanocubes, while being non-toxic and bio-compatible, hold great promise as excellent dual-mode T1 and T2 contrast agents for MRI. ASTAR (Agency for Sci., Tech. and Research, S’pore) Published version 2016-03-15T08:41:56Z 2019-12-06T15:00:38Z 2016-03-15T08:41:56Z 2019-12-06T15:00:38Z 2015 Journal Article Sharma, V. K., Alipour, A., Soran-Erdem, Z., Aykut, Z. G., & Demir, H. V. (2015). Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents. Nanoscale, 7(23), 10519-10526. 2040-3364 https://hdl.handle.net/10356/82700 http://hdl.handle.net/10220/40290 10.1039/C5NR00752F en Nanoscale This article is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported Licence. 8 p. application/pdf |
| spellingShingle | Nanotechnology Sharma, Vijay Kumar Alipour, A. Soran-Erdem, Z. Aykut, Z. G. Demir, Hilmi Volkan Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents |
| title | Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents |
| title_full | Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents |
| title_fullStr | Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents |
| title_full_unstemmed | Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents |
| title_short | Highly monodisperse low-magnetization magnetite nanocubes as simultaneous T1–T2 MRI contrast agents |
| title_sort | highly monodisperse low magnetization magnetite nanocubes as simultaneous t1 t2 mri contrast agents |
| topic | Nanotechnology |
| url | https://hdl.handle.net/10356/82700 http://hdl.handle.net/10220/40290 |
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