Advances in Neutrophil Testing In Type 2 Diabetes Mellitus
Patients with type 2 diabetes mellitus (T2DM) suffer from impaired glucose metabolism which results in low-grade inflammation and activation of the innate immune system. Neutrophils the key effector cells of the innate immune system and heavily implicated in the pathogenesis of T2DM, are promising c...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/83026 http://hdl.handle.net/10220/42383 https://juniperpublishers.com/crdoj/pdf/CRDOJ.MS.ID.555572.pdf |
| _version_ | 1826122697898196992 |
|---|---|
| author | Tay, Hui Min Hou, Han Wei Dalan, Rinkoo Boehm, Bernhard Otto |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tay, Hui Min Hou, Han Wei Dalan, Rinkoo Boehm, Bernhard Otto |
| author_sort | Tay, Hui Min |
| collection | NTU |
| description | Patients with type 2 diabetes mellitus (T2DM) suffer from impaired glucose metabolism which results in low-grade inflammation and activation of the innate immune system. Neutrophils the key effector cells of the innate immune system and heavily implicated in the pathogenesis of T2DM, are promising cell-based inflammatory biomarkers for immune health profiling, provided that they can be rapidly purified and measured with sufficient precision. In this review, we highlight recent advances in neutrophil isolation and functional assay using microfluidics technologies and the potential of their functional phenotype as a novel biomarker of vascular risk in diabetes. |
| first_indexed | 2024-10-01T05:52:26Z |
| format | Journal Article |
| id | ntu-10356/83026 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:52:26Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/830262020-11-01T05:22:00Z Advances in Neutrophil Testing In Type 2 Diabetes Mellitus Tay, Hui Min Hou, Han Wei Dalan, Rinkoo Boehm, Bernhard Otto Lee Kong Chian School of Medicine (LKCMedicine) Neutrophils Diabetes Patients with type 2 diabetes mellitus (T2DM) suffer from impaired glucose metabolism which results in low-grade inflammation and activation of the innate immune system. Neutrophils the key effector cells of the innate immune system and heavily implicated in the pathogenesis of T2DM, are promising cell-based inflammatory biomarkers for immune health profiling, provided that they can be rapidly purified and measured with sufficient precision. In this review, we highlight recent advances in neutrophil isolation and functional assay using microfluidics technologies and the potential of their functional phenotype as a novel biomarker of vascular risk in diabetes. MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Published version 2017-05-11T09:01:26Z 2019-12-06T15:10:28Z 2017-05-11T09:01:26Z 2019-12-06T15:10:28Z 2017 Journal Article Hou, H. W., Tay, H. M., Dalan, R., & Boehm, B. O. (2017). Advances in Neutrophil Testing In Type 2 Diabetes Mellitus. Current Research in Diabetes & Obesity Journal, 1(5), 555572-. 2476-1435 https://hdl.handle.net/10356/83026 http://hdl.handle.net/10220/42383 https://juniperpublishers.com/crdoj/pdf/CRDOJ.MS.ID.555572.pdf en Current Research in Diabetes & Obesity Journal This work is licensed under Creative Commons Attribution 4.0 License 5 p. application/pdf |
| spellingShingle | Neutrophils Diabetes Tay, Hui Min Hou, Han Wei Dalan, Rinkoo Boehm, Bernhard Otto Advances in Neutrophil Testing In Type 2 Diabetes Mellitus |
| title | Advances in Neutrophil Testing In Type 2 Diabetes Mellitus |
| title_full | Advances in Neutrophil Testing In Type 2 Diabetes Mellitus |
| title_fullStr | Advances in Neutrophil Testing In Type 2 Diabetes Mellitus |
| title_full_unstemmed | Advances in Neutrophil Testing In Type 2 Diabetes Mellitus |
| title_short | Advances in Neutrophil Testing In Type 2 Diabetes Mellitus |
| title_sort | advances in neutrophil testing in type 2 diabetes mellitus |
| topic | Neutrophils Diabetes |
| url | https://hdl.handle.net/10356/83026 http://hdl.handle.net/10220/42383 https://juniperpublishers.com/crdoj/pdf/CRDOJ.MS.ID.555572.pdf |
| work_keys_str_mv | AT tayhuimin advancesinneutrophiltestingintype2diabetesmellitus AT houhanwei advancesinneutrophiltestingintype2diabetesmellitus AT dalanrinkoo advancesinneutrophiltestingintype2diabetesmellitus AT boehmbernhardotto advancesinneutrophiltestingintype2diabetesmellitus |