Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

The tuberculosis drug bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using the purified ε subunit of the synthase and spectroscopy, we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here, we show that replacement...

Detaylı Bibliyografya
Asıl Yazarlar:	Kundu, Subhashri, Biukovic, Goran, Grüber, Gerhard, Dick, Thomas
Diğer Yazarlar:	School of Biological Sciences
Materyal Türü:	Journal Article
Dil:	English
Baskı/Yayın Bilgisi:	2017
Konular:	F-ATP synthase ε subunit
Online Erişim:	https://hdl.handle.net/10356/83045 http://hdl.handle.net/10220/42376

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