Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity
Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever s...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/83192 http://hdl.handle.net/10220/42446 |
| _version_ | 1824456302223425536 |
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| author | Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen |
| author_sort | Tang, Tommy Hing-Cheung |
| collection | NTU |
| description | Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence. |
| first_indexed | 2025-02-19T03:51:56Z |
| format | Journal Article |
| id | ntu-10356/83192 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:51:56Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/831922020-11-01T05:32:07Z Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen Lee Kong Chian School of Medicine (LKCMedicine) Serum hyaluronic acid (HA) Plasma Leakage Plasma leakage is a major pathogenic mechanism of severe dengue, but the etiology remains unclear. The association between endothelial glycocalyx integrity and vascular permeability in older adults with dengue has not been evaluated. A prospective cohort study of adults with undifferentiated fever screened for dengue by RT-PCR or NS1 antigen testing was performed. Patients were assessed daily while symptomatic and at convalescence. NMRC (Natl Medical Research Council, S’pore) Published version 2017-05-17T07:53:08Z 2019-12-06T15:13:44Z 2017-05-17T07:53:08Z 2019-12-06T15:13:44Z 2017 Journal Article Tang, T. H. -C., Alonso, S., Ng, L. F. -P., Thein, T. -L., Pang, V. J. -X., Leo, Y. -S., et al. (2017). Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity. Scientific Reports, 7, 46191-. 2045-2322 https://hdl.handle.net/10356/83192 http://hdl.handle.net/10220/42446 10.1038/srep46191 en Scientific Reports This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 9 p. application/pdf |
| spellingShingle | Serum hyaluronic acid (HA) Plasma Leakage Tang, Tommy Hing-Cheung Alonso, Sylvie Ng, Lisa Fong-Poh Thein, Tun-Linn Pang, Vincent Jun-Xiong Leo, Yee-Sin Lye, David Chien-Boon Yeo, Tsin-Wen Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity |
| title | Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity |
| title_full | Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity |
| title_fullStr | Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity |
| title_full_unstemmed | Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity |
| title_short | Increased Serum Hyaluronic Acid and Heparan Sulfate in Dengue Fever: Association with Plasma Leakage and Disease Severity |
| title_sort | increased serum hyaluronic acid and heparan sulfate in dengue fever association with plasma leakage and disease severity |
| topic | Serum hyaluronic acid (HA) Plasma Leakage |
| url | https://hdl.handle.net/10356/83192 http://hdl.handle.net/10220/42446 |
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