Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor
A remarkable feature of biomaterials is their ability to deform in response to certain external bio-stimuli. Here, a novel biochemo-electro-mechanical model is developed for the numerical characterization of the urea-sensitive hydrogel in response to the external stimulus of urea. The urea sensitivi...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/83238 http://hdl.handle.net/10220/42498 |
| _version_ | 1824456343095869440 |
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| author | Li, Hua Goh, K. B. Lam, Khin Yong |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Li, Hua Goh, K. B. Lam, Khin Yong |
| author_sort | Li, Hua |
| collection | NTU |
| description | A remarkable feature of biomaterials is their ability to deform in response to certain external bio-stimuli. Here, a novel biochemo-electro-mechanical model is developed for the numerical characterization of the urea-sensitive hydrogel in response to the external stimulus of urea. The urea sensitivity of the hydrogel is usually characterized by the states of ionization and denaturation of the immobilized urease, as such the model includes the effect of the fixed charge groups and temperature coupled with pH on the activity of the urease. Therefore, a novel rate of reaction equation is proposed to characterize the hydrolysis of urea that accounts for both the ionization and denaturation states of the urease subject to the environmental conditions. After examination with the published experimental data, it is thus confirmed that the model can characterize well the responsive behavior of the urea-sensitive hydrogel subject to the urea stimulus, including the distribution patterns of the electrical potential and pH of the hydrogel. The results point to an innovative means for generating electrical power via the enzyme-induced pH and electrical potential gradients, when the hydrogel comes in contact with the urea-rich solution, such as human urine. |
| first_indexed | 2025-02-19T03:52:35Z |
| format | Journal Article |
| id | ntu-10356/83238 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:52:35Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/832382023-03-04T17:15:05Z Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor Li, Hua Goh, K. B. Lam, Khin Yong School of Mechanical and Aerospace Engineering Multiphysics model Urea-sensitive hydrogel A remarkable feature of biomaterials is their ability to deform in response to certain external bio-stimuli. Here, a novel biochemo-electro-mechanical model is developed for the numerical characterization of the urea-sensitive hydrogel in response to the external stimulus of urea. The urea sensitivity of the hydrogel is usually characterized by the states of ionization and denaturation of the immobilized urease, as such the model includes the effect of the fixed charge groups and temperature coupled with pH on the activity of the urease. Therefore, a novel rate of reaction equation is proposed to characterize the hydrolysis of urea that accounts for both the ionization and denaturation states of the urease subject to the environmental conditions. After examination with the published experimental data, it is thus confirmed that the model can characterize well the responsive behavior of the urea-sensitive hydrogel subject to the urea stimulus, including the distribution patterns of the electrical potential and pH of the hydrogel. The results point to an innovative means for generating electrical power via the enzyme-induced pH and electrical potential gradients, when the hydrogel comes in contact with the urea-rich solution, such as human urine. Accepted version 2017-05-26T06:55:01Z 2019-12-06T15:18:07Z 2017-05-26T06:55:01Z 2019-12-06T15:18:07Z 2017 Journal Article Goh, K. B., Li, H., & Lam, K. Y. (2017). Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor. Biosensors and Bioelectronics, 91, 673-679. 0956-5663 https://hdl.handle.net/10356/83238 http://hdl.handle.net/10220/42498 10.1016/j.bios.2017.01.023 en Biosensors and Bioelectronics © 2017 Elsevier B. V. This is the author created version of a work that has been peer reviewed and accepted for publication by Biosensors and Bioelectronics, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.bios.2017.01.023]. 26 p. application/pdf |
| spellingShingle | Multiphysics model Urea-sensitive hydrogel Li, Hua Goh, K. B. Lam, Khin Yong Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor |
| title | Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor |
| title_full | Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor |
| title_fullStr | Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor |
| title_full_unstemmed | Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor |
| title_short | Development of a multiphysics model to characterize the responsive behavior of urea-sensitive hydrogel as biosensor |
| title_sort | development of a multiphysics model to characterize the responsive behavior of urea sensitive hydrogel as biosensor |
| topic | Multiphysics model Urea-sensitive hydrogel |
| url | https://hdl.handle.net/10356/83238 http://hdl.handle.net/10220/42498 |
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