Studies on the synthesis of the lasubine alkaloids
Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine.
| Main Authors: | , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/83262 http://hdl.handle.net/10220/50081 |
| _version_ | 1826126024592588800 |
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| author | Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland |
| author_sort | Simon, Oliver |
| collection | NTU |
| description | Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine. |
| first_indexed | 2024-10-01T06:45:58Z |
| format | Journal Article |
| id | ntu-10356/83262 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:45:58Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/832622023-02-28T19:32:31Z Studies on the synthesis of the lasubine alkaloids Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland School of Physical and Mathematical Sciences Alkaloid Indolizidine Science::Chemistry::Organic chemistry Formal syntheses of lasubine II and subcosine II have been completed by the synthesis of epi-lasubine II. The synthesis involves diastereoselective allylation of a methoxy isoxazolidine and a tandem hydrogenation process leading stereoselectively to a trisubstituted piperidine. EDB (Economic Devt. Board, S’pore) Accepted version 2019-10-03T08:30:41Z 2019-12-06T15:18:41Z 2019-10-03T08:30:41Z 2019-12-06T15:18:41Z 2018 Journal Article Nur Filza Mohamed Aslam, Simon, O., & Bates, R. W. (2018). Studies on the synthesis of the lasubine alkaloids. Tetrahedron, 74(38), 5032-5039. doi:10.1016/j.tet.2018.06.031 0040-4020 https://hdl.handle.net/10356/83262 http://hdl.handle.net/10220/50081 10.1016/j.tet.2018.06.031 en Tetrahedron © 2018 Elsevier. All rights reserved. This paper was published in Tetrahedron and is made available with permission of Elsevier. 8 p. application/pdf |
| spellingShingle | Alkaloid Indolizidine Science::Chemistry::Organic chemistry Simon, Oliver Nur Filza Mohamed Aslam Bates, Roderick Wayland Studies on the synthesis of the lasubine alkaloids |
| title | Studies on the synthesis of the lasubine alkaloids |
| title_full | Studies on the synthesis of the lasubine alkaloids |
| title_fullStr | Studies on the synthesis of the lasubine alkaloids |
| title_full_unstemmed | Studies on the synthesis of the lasubine alkaloids |
| title_short | Studies on the synthesis of the lasubine alkaloids |
| title_sort | studies on the synthesis of the lasubine alkaloids |
| topic | Alkaloid Indolizidine Science::Chemistry::Organic chemistry |
| url | https://hdl.handle.net/10356/83262 http://hdl.handle.net/10220/50081 |
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