Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction
Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infra...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/83301 http://hdl.handle.net/10220/50094 |
| _version_ | 1811691228866019328 |
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| author | Li, Jingchao Huang, Jiaguo Fan, Quli Xie, Chen Zhang, Xiaodong Jiang, Yuyan Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Li, Jingchao Huang, Jiaguo Fan, Quli Xie, Chen Zhang, Xiaodong Jiang, Yuyan Pu, Kanyi |
| author_sort | Li, Jingchao |
| collection | NTU |
| description | Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infrared (NIR-II)
fluorescent molecular semiconductor (CDIR2) is synthesized for realtime
imaging of kidney dysfunction in living mice. CDIR2 not only has
a high renal clearance efficiency (~90% injection dosage at 24 h postinjection),
but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real-time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR-II fluorescent agents. |
| first_indexed | 2024-10-01T06:16:34Z |
| format | Journal Article |
| id | ntu-10356/83301 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:16:34Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/833012023-12-29T06:50:29Z Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction Li, Jingchao Huang, Jiaguo Fan, Quli Xie, Chen Zhang, Xiaodong Jiang, Yuyan Pu, Kanyi School of Chemical and Biomedical Engineering Real-time Imaging Kidney Dysfunction Engineering::Chemical engineering Real-time imaging of kidney function is important to assess the nephrotoxicity of drugs and monitor the progression of renal diseases; however, it remains challenging because of the lack of optical agents with high renal clearance and high signal-tobackground ratio (SBR). Herein, a second near-infrared (NIR-II) fluorescent molecular semiconductor (CDIR2) is synthesized for realtime imaging of kidney dysfunction in living mice. CDIR2 not only has a high renal clearance efficiency (~90% injection dosage at 24 h postinjection), but also solely undergoes glomerular filtration into urine without being reabsorbed and secreted in renal tubules. Such a unidirectional renal clearance pathway of CDIR2 permits real-time monitoring of kidney dysfunction in living mice upon nephrotoxic exposure. Thus, this study not only introduces a molecular renal probe but also provides useful molecular guidelines to increase the renal clearance efficiency of NIR-II fluorescent agents. MOE (Min. of Education, S’pore) Accepted version 2019-10-08T02:27:41Z 2019-12-06T15:19:34Z 2019-10-08T02:27:41Z 2019-12-06T15:19:34Z 2019 2019 Journal Article Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019). Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction. Angewandte Chemie International Edition, 58(42), 15120-15127. doi:10.1002/anie.201909560 1433-7851 https://hdl.handle.net/10356/83301 http://hdl.handle.net/10220/50094 10.1002/anie.201909560 214920 en Angewandte Chemie International Edition This is the peer reviewed version of the following article: Huang, J., Xie, C., Zhang, X., Jiang, Y., Li, J., Fan, Q., & Pu, K. (2019). Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction. Angewandte Chemie International Edition, 58(42), 15120-15127, which has been published in final form at https://doi.org/10.1002/anie.201909560. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. 8 p. application/pdf |
| spellingShingle | Real-time Imaging Kidney Dysfunction Engineering::Chemical engineering Li, Jingchao Huang, Jiaguo Fan, Quli Xie, Chen Zhang, Xiaodong Jiang, Yuyan Pu, Kanyi Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction |
| title | Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction |
| title_full | Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction |
| title_fullStr | Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction |
| title_full_unstemmed | Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction |
| title_short | Renal-clearable molecular semiconductor for second near-infrared fluorescence imaging of kidney dysfunction |
| title_sort | renal clearable molecular semiconductor for second near infrared fluorescence imaging of kidney dysfunction |
| topic | Real-time Imaging Kidney Dysfunction Engineering::Chemical engineering |
| url | https://hdl.handle.net/10356/83301 http://hdl.handle.net/10220/50094 |
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