Roles of computational modelling in understanding p53 structure, biology, and its therapeutic targeting
The transcription factor p53 plays pivotal roles in numerous biological processes, including the suppression of tumours. The rich availability of biophysical data aimed at understanding its structure–function relationships since the 1990s has enabled the application of a variety of computational mod...
Main Authors: | Tan, Yaw Sing, Mhoumadi, Yasmina, Verma, Chandra Shekhar |
---|---|
Other Authors: | Lane, David P |
Format: | Journal Article |
Language: | English |
Published: |
2019
|
Subjects: | |
Online Access: | https://hdl.handle.net/10356/83525 http://hdl.handle.net/10220/49762 |
Similar Items
-
Domain-specific p53 mutants activate EGFR by distinct mechanisms exposing tissue-independent therapeutic vulnerabilities
by: Ho, Teresa Lai Fong, et al.
Published: (2023) -
The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans
by: Venkatesh, Byrappa, et al.
Published: (2016) -
Simulations of mutant p53 DNA binding domains reveal a novel druggable pocket
by: Siau, Jia Wei, et al.
Published: (2019) -
Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch
by: Chong, Ket Hing, et al.
Published: (2020) -
Rapid recruitment of p53 to DNA damage sites directs DNA repair choice and integrity
by: Wang, Yu-Hsiu, et al.
Published: (2022)