The Immunosenescence of αβ & γδ T cells in human blood and skin
Studies in human aging mainly focus on αβ T cells while γδ T cells and skin-resident T cells have been neglected despite their role in immunosurveillance. In this thesis, we showed that peripheral Vδ2+ are differentially susceptible to life-long stresses as compared to other αβ and γδ T cells. Using...
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| Other Authors: | |
| Format: | Thesis |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/83643 http://hdl.handle.net/10220/47613 |
| _version_ | 1811685905886347264 |
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| author | Xu, Weili |
| author2 | Anis Larbi |
| author_facet | Anis Larbi Xu, Weili |
| author_sort | Xu, Weili |
| collection | NTU |
| description | Studies in human aging mainly focus on αβ T cells while γδ T cells and skin-resident T cells have been neglected despite their role in immunosurveillance. In this thesis, we showed that peripheral Vδ2+ are differentially susceptible to life-long stresses as compared to other αβ and γδ T cells. Using aging, cytomegalovirus history as immunological models and via the different functional assays, we show that Vδ2+ T cells are protected from cellular senescence. Next, we also investigated the skin-resident T cells and show that they are also differentially susceptible to life-long stresses as compared to periphery T cells. In conclusion, this shows that not all immune cells in the host undergo similar process of immunosenescence and the underlying biology and mechanisms behind Vδ2+ and skin-resident T cells’ protection from cellular senescence with age could be exploited as possible interventions to other cell types or by itself to mitigate the “grey tsunami”. |
| first_indexed | 2024-10-01T04:51:57Z |
| format | Thesis |
| id | ntu-10356/83643 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:51:57Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/836432023-02-28T18:39:04Z The Immunosenescence of αβ & γδ T cells in human blood and skin Xu, Weili Anis Larbi School of Biological Sciences A*STAR Singapore Immunology Network DRNTU::Science::Biological sciences Studies in human aging mainly focus on αβ T cells while γδ T cells and skin-resident T cells have been neglected despite their role in immunosurveillance. In this thesis, we showed that peripheral Vδ2+ are differentially susceptible to life-long stresses as compared to other αβ and γδ T cells. Using aging, cytomegalovirus history as immunological models and via the different functional assays, we show that Vδ2+ T cells are protected from cellular senescence. Next, we also investigated the skin-resident T cells and show that they are also differentially susceptible to life-long stresses as compared to periphery T cells. In conclusion, this shows that not all immune cells in the host undergo similar process of immunosenescence and the underlying biology and mechanisms behind Vδ2+ and skin-resident T cells’ protection from cellular senescence with age could be exploited as possible interventions to other cell types or by itself to mitigate the “grey tsunami”. Doctor of Philosophy 2019-02-04T03:25:17Z 2019-12-06T15:27:22Z 2019-02-04T03:25:17Z 2019-12-06T15:27:22Z 2019 Thesis Xu, W. (2019). The Immunosenescence of αβ & γδ T cells in human blood and skin. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/83643 http://hdl.handle.net/10220/47613 10.32657/10220/47613 en 176 p. application/pdf |
| spellingShingle | DRNTU::Science::Biological sciences Xu, Weili The Immunosenescence of αβ & γδ T cells in human blood and skin |
| title | The Immunosenescence of αβ & γδ T cells in human blood and skin |
| title_full | The Immunosenescence of αβ & γδ T cells in human blood and skin |
| title_fullStr | The Immunosenescence of αβ & γδ T cells in human blood and skin |
| title_full_unstemmed | The Immunosenescence of αβ & γδ T cells in human blood and skin |
| title_short | The Immunosenescence of αβ & γδ T cells in human blood and skin |
| title_sort | immunosenescence of αβ γδ t cells in human blood and skin |
| topic | DRNTU::Science::Biological sciences |
| url | https://hdl.handle.net/10356/83643 http://hdl.handle.net/10220/47613 |
| work_keys_str_mv | AT xuweili theimmunosenescenceofabgdtcellsinhumanbloodandskin AT xuweili immunosenescenceofabgdtcellsinhumanbloodandskin |