Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging
Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rare and limited to inorganic nanoparticles. This study reports the design prin...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Online Access: | https://hdl.handle.net/10356/83793 http://hdl.handle.net/10220/42783 |
| _version_ | 1811682305275592704 |
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| author | Zhen, Xu Tao, Ye An, Zhongfu Chen, Peng Xu, Chenjie Chen, Runfeng Huang, Wei Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhen, Xu Tao, Ye An, Zhongfu Chen, Peng Xu, Chenjie Chen, Runfeng Huang, Wei Pu, Kanyi |
| author_sort | Zhen, Xu |
| collection | NTU |
| description | Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rare and limited to inorganic nanoparticles. This study reports the design principle, synthesis, and proof-of-concept application of organic semiconducting nanoparticles (OSNs) with ultralong phosphorescence for in vivo afterglow imaging. The design principle leverages the formation of aggregates through a top-down nanoparticle formulation to greatly stabilize the triplet excited states of a phosphorescent molecule. This prolongs the particle luminesce to the timescale that can be detected by the commercial whole-animal imaging system after removal of external light source. Such ultralong phosphorescent of OSNs is inert to oxygen and can be repeatedly activated, permitting imaging of lymph nodes in living mice with a high signal-to-noise ratio. This study not only introduces the first category of water-soluble ultralong phosphorescence organic nanoparticles but also reveals a universal design principle to prolong the lifetime of phosphorescent molecules to the level that can be effective for molecular imaging. |
| first_indexed | 2024-10-01T03:54:44Z |
| format | Journal Article |
| id | ntu-10356/83793 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:54:44Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/837932023-12-29T06:47:11Z Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging Zhen, Xu Tao, Ye An, Zhongfu Chen, Peng Xu, Chenjie Chen, Runfeng Huang, Wei Pu, Kanyi School of Chemical and Biomedical Engineering Lymph Node Imaging Afterglow Afterglow or persistent luminescence eliminates the need for light excitation and thus circumvents the issue of autofluorescence, holding promise for molecular imaging. However, current persistent luminescence agents are rare and limited to inorganic nanoparticles. This study reports the design principle, synthesis, and proof-of-concept application of organic semiconducting nanoparticles (OSNs) with ultralong phosphorescence for in vivo afterglow imaging. The design principle leverages the formation of aggregates through a top-down nanoparticle formulation to greatly stabilize the triplet excited states of a phosphorescent molecule. This prolongs the particle luminesce to the timescale that can be detected by the commercial whole-animal imaging system after removal of external light source. Such ultralong phosphorescent of OSNs is inert to oxygen and can be repeatedly activated, permitting imaging of lymph nodes in living mice with a high signal-to-noise ratio. This study not only introduces the first category of water-soluble ultralong phosphorescence organic nanoparticles but also reveals a universal design principle to prolong the lifetime of phosphorescent molecules to the level that can be effective for molecular imaging. MOE (Min. of Education, S’pore) Accepted version 2017-07-03T07:41:05Z 2019-12-06T15:32:11Z 2017-07-03T07:41:05Z 2019-12-06T15:32:11Z 2017 2017 Journal Article Zhen, X., Tao, Y., An, Z., Chen, P., Xu, C., Chen, R., et al. (2017). Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging. Advanced Materials, 29(33), 1606665-. 0935-9648 https://hdl.handle.net/10356/83793 http://hdl.handle.net/10220/42783 10.1002/adma.201606665 201983 en Advanced Materials © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is the author created version of a work that has been peer reviewed and accepted for publication by Advanced Materials, WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://doi.org/10.1002/adma.201606665]. 17 p. application/pdf |
| spellingShingle | Lymph Node Imaging Afterglow Zhen, Xu Tao, Ye An, Zhongfu Chen, Peng Xu, Chenjie Chen, Runfeng Huang, Wei Pu, Kanyi Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging |
| title | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging |
| title_full | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging |
| title_fullStr | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging |
| title_full_unstemmed | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging |
| title_short | Ultralong Phosphorescence of Water-Soluble Organic Nanoparticles for In Vivo Afterglow Imaging |
| title_sort | ultralong phosphorescence of water soluble organic nanoparticles for in vivo afterglow imaging |
| topic | Lymph Node Imaging Afterglow |
| url | https://hdl.handle.net/10356/83793 http://hdl.handle.net/10220/42783 |
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