Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides
Background: Bioactive peptides with antimicrobial properties have many potential applications, ranging from food preservation to the treatment of drug-resistant infections. However, some of these peptides may induce unwanted toxicity or immunogenicity. Regulatory agencies, therefore, require rigours...
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| Other Authors: | |
| Format: | Student Research Poster |
| Language: | English |
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2016
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| Online Access: | https://hdl.handle.net/10356/84143 http://hdl.handle.net/10220/41624 |
| _version_ | 1826116392913469440 |
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| author | Koh, Phay Chung |
| author2 | Navin Kumar Verma |
| author_facet | Navin Kumar Verma Koh, Phay Chung |
| author_sort | Koh, Phay Chung |
| collection | NTU |
| description | Background: Bioactive peptides with antimicrobial properties have many potential applications, ranging from food preservation to the treatment of drug-resistant infections. However, some of these peptides may induce unwanted toxicity or immunogenicity. Regulatory agencies, therefore, require rigours safety assessments of all the therapeutic peptides using appropriate biological model systems. Our collaborating group has developed a novel series of AMPs with broad spectrum antimicrobial activities. Aim: To examine possible cytotoxicity and immunogenicity (if any) of the four AMPs (Pep 1, Pep 2, Pep 3, & Pep 4) using cell culture model systems. [2nd Award] |
| first_indexed | 2024-10-01T04:10:58Z |
| format | Student Research Poster |
| id | ntu-10356/84143 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:10:58Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/841432020-09-27T20:28:27Z Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides Koh, Phay Chung Navin Kumar Verma Lee Kong Chian School of Medicine (LKCMedicine) Antimicrobial peptide Immunogenicity Background: Bioactive peptides with antimicrobial properties have many potential applications, ranging from food preservation to the treatment of drug-resistant infections. However, some of these peptides may induce unwanted toxicity or immunogenicity. Regulatory agencies, therefore, require rigours safety assessments of all the therapeutic peptides using appropriate biological model systems. Our collaborating group has developed a novel series of AMPs with broad spectrum antimicrobial activities. Aim: To examine possible cytotoxicity and immunogenicity (if any) of the four AMPs (Pep 1, Pep 2, Pep 3, & Pep 4) using cell culture model systems. [2nd Award] 2016-11-04T05:04:22Z 2019-12-06T15:39:13Z 2016-11-04T05:04:22Z 2019-12-06T15:39:13Z 2016 Student Research Poster Koh, P. C. (2016, March). Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides. Presented at Discover URECA @ NTU poster exhibition and competition, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/84143 http://hdl.handle.net/10220/41624 en © 2016 Author(s). application/pdf |
| spellingShingle | Antimicrobial peptide Immunogenicity Koh, Phay Chung Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| title | Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| title_full | Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| title_fullStr | Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| title_full_unstemmed | Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| title_short | Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| title_sort | preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides |
| topic | Antimicrobial peptide Immunogenicity |
| url | https://hdl.handle.net/10356/84143 http://hdl.handle.net/10220/41624 |
| work_keys_str_mv | AT kohphaychung preclinicalsafetyandimmunogenicityevaluationofbioactiveantimicrobialpeptides |