Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering
A solvent-free melt-drawing of aligned poly(L-lactide-co-ε-caprolactone) copolymer (PLC) microfibers into the tubular scaffold with the endocircular and exolongitudinal patterns has been investigated for the esophageal tissue engineering. The PLC microfibrous tubular scaffold was melt-drawn onto the...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
| Published: |
2016
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| Online Access: | https://hdl.handle.net/10356/84201 http://hdl.handle.net/10220/41675 |
| _version_ | 1811684692470005760 |
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| author | Tan, Yu Jun An, Jia Foo, Yong Sheng Yeong, Wai Yee Leong, Kah Fai |
| author2 | School of Mechanical and Aerospace Engineering |
| author_facet | School of Mechanical and Aerospace Engineering Tan, Yu Jun An, Jia Foo, Yong Sheng Yeong, Wai Yee Leong, Kah Fai |
| author_sort | Tan, Yu Jun |
| collection | NTU |
| description | A solvent-free melt-drawing of aligned poly(L-lactide-co-ε-caprolactone) copolymer (PLC) microfibers into the tubular scaffold with the endocircular and exolongitudinal patterns has been investigated for the esophageal tissue engineering. The PLC microfibrous tubular scaffold was melt-drawn onto the 3D printed grooved mandrel. The experimental results show that the parallel grooves normal to the microfiber direction formed on the inner surface of the tubular scaffold. The surface topography of the tubular scaffold will mimic the endocircular and exolongitudinal muscle layers of the esophagus when the scaffold is turned inside out. It is proposed that this surface architecture may induce the cells orientation and cells attachment during its interaction with the individual smooth muscle cell. A large shrinkage of scaffold in dimension is observed along the fiber direction after the removal of scaffold from mandrel, which indicates that the PLC scaffold has a high elasticity. Therefore, the PLC scaffold will be mechanically compatible with the esophagus. Furthermore, it is suggested that the melt-drawing could be combined with the bioprinting technologies to print the tubular organs efficiently. |
| first_indexed | 2024-10-01T04:32:40Z |
| format | Conference Paper |
| id | ntu-10356/84201 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:32:40Z |
| publishDate | 2016 |
| record_format | dspace |
| spelling | ntu-10356/842012020-09-24T20:12:02Z Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering Tan, Yu Jun An, Jia Foo, Yong Sheng Yeong, Wai Yee Leong, Kah Fai School of Mechanical and Aerospace Engineering Proceedings of the 1st International Conference on Progress in Additive Manufacturing (Pro-AM 2014) Singapore Centre for 3D Printing Tissue engineering Polymer microfiber A solvent-free melt-drawing of aligned poly(L-lactide-co-ε-caprolactone) copolymer (PLC) microfibers into the tubular scaffold with the endocircular and exolongitudinal patterns has been investigated for the esophageal tissue engineering. The PLC microfibrous tubular scaffold was melt-drawn onto the 3D printed grooved mandrel. The experimental results show that the parallel grooves normal to the microfiber direction formed on the inner surface of the tubular scaffold. The surface topography of the tubular scaffold will mimic the endocircular and exolongitudinal muscle layers of the esophagus when the scaffold is turned inside out. It is proposed that this surface architecture may induce the cells orientation and cells attachment during its interaction with the individual smooth muscle cell. A large shrinkage of scaffold in dimension is observed along the fiber direction after the removal of scaffold from mandrel, which indicates that the PLC scaffold has a high elasticity. Therefore, the PLC scaffold will be mechanically compatible with the esophagus. Furthermore, it is suggested that the melt-drawing could be combined with the bioprinting technologies to print the tubular organs efficiently. Published version 2016-12-05T07:58:39Z 2019-12-06T15:40:25Z 2016-12-05T07:58:39Z 2019-12-06T15:40:25Z 2014 Conference Paper Tan, Y. J., An, J., Foo, Y. S., Yeong, W. Y., & Leong, K. F. (2014). Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering. Proceedings of the 1st International Conference on Progress in Additive Manufacturing (Pro-AM 2014), 78-84. https://hdl.handle.net/10356/84201 http://hdl.handle.net/10220/41675 10.3850/978-981-09-0446-3_031 en © 2014 by Research Publishing Services. 7 p. application/pdf |
| spellingShingle | Tissue engineering Polymer microfiber Tan, Yu Jun An, Jia Foo, Yong Sheng Yeong, Wai Yee Leong, Kah Fai Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering |
| title | Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering |
| title_full | Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering |
| title_fullStr | Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering |
| title_full_unstemmed | Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering |
| title_short | Solvent-Free Melt-Drawing of Aligned Poly(L-Lactide-Co-ε-Caprolactone) Microfibres into Tubular Scaffold for Esophageal Tissue Engineering |
| title_sort | solvent free melt drawing of aligned poly l lactide co ε caprolactone microfibres into tubular scaffold for esophageal tissue engineering |
| topic | Tissue engineering Polymer microfiber |
| url | https://hdl.handle.net/10356/84201 http://hdl.handle.net/10220/41675 |
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