Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa
Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as r...
| Main Authors: | , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/84292 http://hdl.handle.net/10220/45112 |
| _version_ | 1811676865937539072 |
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| author | Simam, Joan Rono, Martin Ngoi, Joyce Nyonda, Mary Mok, Sachel Marsh, Kevin Bozdech, Zbynek Mackinnon, Margaret |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Simam, Joan Rono, Martin Ngoi, Joyce Nyonda, Mary Mok, Sachel Marsh, Kevin Bozdech, Zbynek Mackinnon, Margaret |
| author_sort | Simam, Joan |
| collection | NTU |
| description | Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as red cell invasion, transmissibility and cytoadherence. Studies of natural parasite populations indicate that CNVs are also common in the field and thus may facilitate adaptation of the parasite to its local environment. |
| first_indexed | 2024-10-01T02:28:16Z |
| format | Journal Article |
| id | ntu-10356/84292 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:28:16Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/842922023-02-28T16:59:49Z Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa Simam, Joan Rono, Martin Ngoi, Joyce Nyonda, Mary Mok, Sachel Marsh, Kevin Bozdech, Zbynek Mackinnon, Margaret School of Biological Sciences Plasmodium Falciparum Copy Number Variation Gene copy number variants (CNVs), which consist of deletions and amplifications of single or sets of contiguous genes, contribute to the great diversity in the Plasmodium falciparum genome. In vitro studies in the laboratory have revealed their important role in parasite fitness phenotypes such as red cell invasion, transmissibility and cytoadherence. Studies of natural parasite populations indicate that CNVs are also common in the field and thus may facilitate adaptation of the parasite to its local environment. Published version 2018-07-18T08:49:06Z 2019-12-06T15:42:13Z 2018-07-18T08:49:06Z 2019-12-06T15:42:13Z 2018 Journal Article Simam, J., Rono, M., Ngoi, J., Nyonda, M., Mok, S., Marsh, K., et al. (2018). Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa. BMC Genomics, 19(1), 372-. 1471-2164 https://hdl.handle.net/10356/84292 http://hdl.handle.net/10220/45112 10.1186/s12864-018-4689-7 en BMC Genomics © 2018 The Author(s). Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. 15 p. application/pdf |
| spellingShingle | Plasmodium Falciparum Copy Number Variation Simam, Joan Rono, Martin Ngoi, Joyce Nyonda, Mary Mok, Sachel Marsh, Kevin Bozdech, Zbynek Mackinnon, Margaret Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa |
| title | Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa |
| title_full | Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa |
| title_fullStr | Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa |
| title_full_unstemmed | Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa |
| title_short | Gene copy number variation in natural populations of Plasmodium falciparum in Eastern Africa |
| title_sort | gene copy number variation in natural populations of plasmodium falciparum in eastern africa |
| topic | Plasmodium Falciparum Copy Number Variation |
| url | https://hdl.handle.net/10356/84292 http://hdl.handle.net/10220/45112 |
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