Cellular automata models of tumour natural shrinkage

In this paper we present three dimensional cellular automata models for tumour growth, with a focus on the tumour’s natural shrinkage caused by the removal of the dead cells’ mortal remains. The significance of this phenomenon for the resulting volume of the in silico tumour is shown. Two algorithms...

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Bibliographic Details
Main Authors: Naumov, Lev., Hoekstra, Alfons G., Sloot, Peter M. A.
Other Authors: School of Computer Engineering
Format: Journal Article
Language:English
Published: 2013
Online Access:https://hdl.handle.net/10356/84323
http://hdl.handle.net/10220/10127
Description
Summary:In this paper we present three dimensional cellular automata models for tumour growth, with a focus on the tumour’s natural shrinkage caused by the removal of the dead cells’ mortal remains. The significance of this phenomenon for the resulting volume of the in silico tumour is shown. Two algorithms are presented, one using the chain shifting approach for tumour expansion and shrinkage and another improving the performance of the chain shifting approach. Simulations are validated against the experimental results.