Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window
Photoacoustic (PA) imaging holds great promise for preclinical research and clinical practice. However, most studies rely on the laser wavelength in the first near-infrared (NIR) window (NIR-I, 650–950 nm), while few studies have been exploited in the second NIR window (NIR-II, 1000–1700 nm), mainly...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/84411 http://hdl.handle.net/10220/43592 |
| _version_ | 1826127857846321152 |
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| author | Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Lyu, Yan Zhang, Lulu Xiong, Qihua Pramanik, Manojit Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Lyu, Yan Zhang, Lulu Xiong, Qihua Pramanik, Manojit Pu, Kanyi |
| author_sort | Jiang, Yuyan |
| collection | NTU |
| description | Photoacoustic (PA) imaging holds great promise for preclinical research and clinical practice. However, most studies rely on the laser wavelength in the first near-infrared (NIR) window (NIR-I, 650–950 nm), while few studies have been exploited in the second NIR window (NIR-II, 1000–1700 nm), mainly due to the lack of NIR-II absorbing contrast agents. We herein report the synthesis of a broadband absorbing PA contrast agent based on semiconducting polymer nanoparticles (SPN-II) and apply it for PA imaging in NIR-II window. SPN-II can absorb in both NIR-I and NIR-II regions, providing the feasibility to directly compare PA imaging at 750 nm with that at 1064 nm. Because of the weaker background PA signals from biological tissues in NIR-II window, the signal-to-noise ratio (SNR) of SPN-II resulted PA images at 1064 nm can be 1.4-times higher than that at 750 nm when comparing at the imaging depth of 3 cm. The proof-of-concept application of NIR-II PA imaging is demonstrated in in vivo imaging of brain vasculature in living rats, which showed 1.5-times higher SNR as compared with NIR-I PA imaging. Our study not only introduces the first broadband absorbing organic contrast agent that is applicable for PA imaging in both NIR-I and NIR-II windows but also reveals the advantages of NIR-II over NIR-I in PA imaging. |
| first_indexed | 2024-10-01T07:15:41Z |
| format | Journal Article |
| id | ntu-10356/84411 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:15:41Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/844112023-02-28T19:33:07Z Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Lyu, Yan Zhang, Lulu Xiong, Qihua Pramanik, Manojit Pu, Kanyi School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences Polymer nanoparticles Photoacoustic imaging Photoacoustic (PA) imaging holds great promise for preclinical research and clinical practice. However, most studies rely on the laser wavelength in the first near-infrared (NIR) window (NIR-I, 650–950 nm), while few studies have been exploited in the second NIR window (NIR-II, 1000–1700 nm), mainly due to the lack of NIR-II absorbing contrast agents. We herein report the synthesis of a broadband absorbing PA contrast agent based on semiconducting polymer nanoparticles (SPN-II) and apply it for PA imaging in NIR-II window. SPN-II can absorb in both NIR-I and NIR-II regions, providing the feasibility to directly compare PA imaging at 750 nm with that at 1064 nm. Because of the weaker background PA signals from biological tissues in NIR-II window, the signal-to-noise ratio (SNR) of SPN-II resulted PA images at 1064 nm can be 1.4-times higher than that at 750 nm when comparing at the imaging depth of 3 cm. The proof-of-concept application of NIR-II PA imaging is demonstrated in in vivo imaging of brain vasculature in living rats, which showed 1.5-times higher SNR as compared with NIR-I PA imaging. Our study not only introduces the first broadband absorbing organic contrast agent that is applicable for PA imaging in both NIR-I and NIR-II windows but also reveals the advantages of NIR-II over NIR-I in PA imaging. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version 2017-08-16T07:07:01Z 2019-12-06T15:44:38Z 2017-08-16T07:07:01Z 2019-12-06T15:44:38Z 2017 2017 Journal Article 14 p. Jiang, Y., Upputuri, P. K., Xie, C., Lyu, Y., Zhang, L., Xiong, Q., et al. (2017). Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window. Nano Letters, 17(8), 4964-4969. 1530-6984 https://hdl.handle.net/10356/84411 http://hdl.handle.net/10220/43592 10.1021/acs.nanolett.7b02106 202091 en Nano Letters © 2017 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Nano Letters, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.nanolett.7b02106]. application/pdf |
| spellingShingle | Polymer nanoparticles Photoacoustic imaging Jiang, Yuyan Upputuri, Paul Kumar Xie, Chen Lyu, Yan Zhang, Lulu Xiong, Qihua Pramanik, Manojit Pu, Kanyi Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window |
| title | Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window |
| title_full | Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window |
| title_fullStr | Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window |
| title_full_unstemmed | Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window |
| title_short | Broadband Absorbing Semiconducting Polymer Nanoparticles for Photoacoustic Imaging in Second Near-Infrared Window |
| title_sort | broadband absorbing semiconducting polymer nanoparticles for photoacoustic imaging in second near infrared window |
| topic | Polymer nanoparticles Photoacoustic imaging |
| url | https://hdl.handle.net/10356/84411 http://hdl.handle.net/10220/43592 |
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