Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy
Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurately and efficiently predict novel non-synonymous SNPs (nsSNPs) that could be causative to g...
| Main Authors: | , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/84498 http://hdl.handle.net/10220/45113 |
| _version_ | 1811694221849001984 |
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| author | Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo |
| author2 | School of Computer Science and Engineering |
| author_facet | School of Computer Science and Engineering Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo |
| author_sort | Limviphuvadh, Vachiranee |
| collection | NTU |
| description | Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurately and efficiently predict novel non-synonymous SNPs (nsSNPs) that could be causative to gemcitabine-based chemotherapy treatment outcome in Singaporean non-small cell lung cancer (NSCLC) patients. |
| first_indexed | 2024-10-01T07:04:08Z |
| format | Journal Article |
| id | ntu-10356/84498 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:04:08Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/844982020-03-07T11:48:56Z Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo School of Computer Science and Engineering Gemcitabine NSCLC Single Nucleotide Polymorphisms (SNPs) can influence patient outcome such as drug response and toxicity after drug intervention. The purpose of this study is to develop a systematic pathway approach to accurately and efficiently predict novel non-synonymous SNPs (nsSNPs) that could be causative to gemcitabine-based chemotherapy treatment outcome in Singaporean non-small cell lung cancer (NSCLC) patients. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) MOE (Min. of Education, S’pore) Published version 2018-07-18T08:51:54Z 2019-12-06T15:46:09Z 2018-07-18T08:51:54Z 2019-12-06T15:46:09Z 2018 Journal Article Limviphuvadh, V., Tan, C. S., Konishi, F., Jenjaroenpun, P., Xiang, J. S., Kremenska, Y., et al. (2018). Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy. BMC Cancer, 18(1), 555-. 1471-2407 https://hdl.handle.net/10356/84498 http://hdl.handle.net/10220/45113 10.1186/s12885-018-4471-x en BMC Cancer © The Author(s). 2018 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. 16 p. application/pdf |
| spellingShingle | Gemcitabine NSCLC Limviphuvadh, Vachiranee Tan, Chee Seng Konishi, Fumikazu Jenjaroenpun, Piroon Xiang, Joy Shengnan Kremenska, Yuliya Mu, Yar Soe Soo, Ross A. Eisenhaber, Frank Maurer-Stroh, Sebastian Yong, Wei Peng Nicholas, Syn Chin, Lee Soo Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy |
| title | Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy |
| title_full | Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy |
| title_fullStr | Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy |
| title_full_unstemmed | Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy |
| title_short | Discovering novel SNPs that are correlated with patient outcome in a Singaporean cancer patient cohort treated with gemcitabine-based chemotherapy |
| title_sort | discovering novel snps that are correlated with patient outcome in a singaporean cancer patient cohort treated with gemcitabine based chemotherapy |
| topic | Gemcitabine NSCLC |
| url | https://hdl.handle.net/10356/84498 http://hdl.handle.net/10220/45113 |
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