Nano-optofluidics for single molecule detection and sorting
This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Conference Paper |
| Language: | English |
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2013
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/84752 http://hdl.handle.net/10220/12467 |
| _version_ | 1824454852385701888 |
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| author | Yang, Y. Tsai, J. M. Liu, A. Q. Kwong, Dim Lee. |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Yang, Y. Tsai, J. M. Liu, A. Q. Kwong, Dim Lee. |
| author_sort | Yang, Y. |
| collection | NTU |
| description | This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting. |
| first_indexed | 2025-02-19T03:28:54Z |
| format | Conference Paper |
| id | ntu-10356/84752 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2025-02-19T03:28:54Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/847522020-03-07T13:24:45Z Nano-optofluidics for single molecule detection and sorting Yang, Y. Tsai, J. M. Liu, A. Q. Kwong, Dim Lee. School of Electrical and Electronic Engineering IEEE International Conference on Micro Electro Mechanical Systems (25th : 2012 : Paris, France) DRNTU::Engineering::Electrical and electronic engineering This paper reports a nano-optofluidic device using evanescent wave sensing for single molecule detection and sorting based on hydrodynamic focusing and total internal reflection (TIR). Nano-sized samples in liquid can be measured and counted even their size is smaller than the diffraction limit. We demonstrated 200-nm nanoparticle detecting which is beyond the diffraction limit. As compared to the conventional TIR microscopy, the nano-optofluidic device can measure and count all samples in real time. It has wide range applications in the single molecule detection, imaging and counting. 2013-07-29T06:51:15Z 2019-12-06T15:50:45Z 2013-07-29T06:51:15Z 2019-12-06T15:50:45Z 2012 2012 Conference Paper Yang, Y., Tsai, J. M., Kwong, D. L., & Liu, A. Q. (2012). Nano-optofluidics for single molecule detection and sorting. 2012 IEEE 25th International Conference on Micro Electro Mechanical Systems (MEMS), 156-159. https://hdl.handle.net/10356/84752 http://hdl.handle.net/10220/12467 10.1109/MEMSYS.2012.6170117 en © 2012 IEEE. |
| spellingShingle | DRNTU::Engineering::Electrical and electronic engineering Yang, Y. Tsai, J. M. Liu, A. Q. Kwong, Dim Lee. Nano-optofluidics for single molecule detection and sorting |
| title | Nano-optofluidics for single molecule detection and sorting |
| title_full | Nano-optofluidics for single molecule detection and sorting |
| title_fullStr | Nano-optofluidics for single molecule detection and sorting |
| title_full_unstemmed | Nano-optofluidics for single molecule detection and sorting |
| title_short | Nano-optofluidics for single molecule detection and sorting |
| title_sort | nano optofluidics for single molecule detection and sorting |
| topic | DRNTU::Engineering::Electrical and electronic engineering |
| url | https://hdl.handle.net/10356/84752 http://hdl.handle.net/10220/12467 |
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