Fast localized single cell membrane poration by bubble-induced jetting flow
This paper demonstrates a new method to porate single suspension living cell membrane using cavitation bubble-induced high speed jet flow. A microfluidic chip with an array of single cell trapping structures is designed and fabricated to trap sing cell and induce the asymmetric collapse of the cavit...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2013
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| Online Access: | https://hdl.handle.net/10356/85069 http://hdl.handle.net/10220/12469 |
| _version_ | 1826126749468983296 |
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| author | Li, Z. G. Ohl, C. D. Zhang, J. B. Tsai, J. Liu, A. Q. |
| author2 | School of Electrical and Electronic Engineering |
| author_facet | School of Electrical and Electronic Engineering Li, Z. G. Ohl, C. D. Zhang, J. B. Tsai, J. Liu, A. Q. |
| author_sort | Li, Z. G. |
| collection | NTU |
| description | This paper demonstrates a new method to porate single suspension living cell membrane using cavitation bubble-induced high speed jet flow. A microfluidic chip with an array of single cell trapping structures is designed and fabricated to trap sing cell and induce the asymmetric collapse of the cavitation bubble. Myeloma cells suspended in Trypan blue saline solution is tested and single Myeloma cells can be trapped in the trapping structures. The dynamic process is recorded using a high speed camera. This method has great potential in biomedical applications and easy to be integrated to other microfluidic system. |
| first_indexed | 2024-10-01T06:57:46Z |
| format | Journal Article |
| id | ntu-10356/85069 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:57:46Z |
| publishDate | 2013 |
| record_format | dspace |
| spelling | ntu-10356/850692020-03-07T13:57:24Z Fast localized single cell membrane poration by bubble-induced jetting flow Li, Z. G. Ohl, C. D. Zhang, J. B. Tsai, J. Liu, A. Q. School of Electrical and Electronic Engineering School of Physical and Mathematical Sciences IEEE International Conference on Micro Electro Mechanical Systems (25th : 2012 : Paris, France) This paper demonstrates a new method to porate single suspension living cell membrane using cavitation bubble-induced high speed jet flow. A microfluidic chip with an array of single cell trapping structures is designed and fabricated to trap sing cell and induce the asymmetric collapse of the cavitation bubble. Myeloma cells suspended in Trypan blue saline solution is tested and single Myeloma cells can be trapped in the trapping structures. The dynamic process is recorded using a high speed camera. This method has great potential in biomedical applications and easy to be integrated to other microfluidic system. 2013-07-29T06:55:42Z 2019-12-06T15:56:30Z 2013-07-29T06:55:42Z 2019-12-06T15:56:30Z 2012 2012 Journal Article Li, Z. G., Ohl, C. D., Zhang, J. B., Tsai, J., & Liu, A. Q. (2012). Fast localized single cell membrane poration by bubble-induced jetting flow. Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS), 819-822. https://hdl.handle.net/10356/85069 http://hdl.handle.net/10220/12469 10.1109/MEMSYS.2012.6170311 en Proceedings of the IEEE international conference on Micro Electro Mechanical Systems (MEMS) © 2012 IEEE. |
| spellingShingle | Li, Z. G. Ohl, C. D. Zhang, J. B. Tsai, J. Liu, A. Q. Fast localized single cell membrane poration by bubble-induced jetting flow |
| title | Fast localized single cell membrane poration by bubble-induced jetting flow |
| title_full | Fast localized single cell membrane poration by bubble-induced jetting flow |
| title_fullStr | Fast localized single cell membrane poration by bubble-induced jetting flow |
| title_full_unstemmed | Fast localized single cell membrane poration by bubble-induced jetting flow |
| title_short | Fast localized single cell membrane poration by bubble-induced jetting flow |
| title_sort | fast localized single cell membrane poration by bubble induced jetting flow |
| url | https://hdl.handle.net/10356/85069 http://hdl.handle.net/10220/12469 |
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