Functional connectivity of resting-state, working memory and inhibition networks in perceived stress
Experimental imaging studies on the effects of acute stress have revealed functional changes in the amygdalae, hippocampi and medial frontal cortices. However, much less is known about the association between perceived stress and neurological function which may have implications for the development...
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| מחברים אחרים: | |
| פורמט: | Journal Article |
| שפה: | English |
| יצא לאור: |
2017
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| נושאים: | |
| גישה מקוונת: | https://hdl.handle.net/10356/85134 http://hdl.handle.net/10220/43645 |
| _version_ | 1826112463005810688 |
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| author | Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing |
| author_sort | Archer, Jo A. |
| collection | NTU |
| description | Experimental imaging studies on the effects of acute stress have revealed functional changes in the amygdalae, hippocampi and medial frontal cortices. However, much less is known about the association between perceived stress and neurological function which may have implications for the development of stress related disorders. Participants completed a working-memory task and an inhibition task whilst undergoing a functional magnetic resonance imaging (fMRI) scan. Task related and resting-state fMRI data from 22 women and 24 men were analysed to investigate changes in task activations and functional connectivity associated with perceived stress over the past month. Analyses were stratified by gender due to gender differences in the stress response. Stress was associated with faster working memory response time in women, but not men. Stress was not associated with any differences in task activations in either gender. There were many significant associations between stress and connectivity: findings in women were consistent with increased emotional regulation; men exhibited decreases in connectivity between affective processing areas during the tasks and showed no relation between perceived stress and resting-state connectivity; very few of the within gender differences were significantly different between gender. Dysregulated connectivity between areas involved in the neural stress response and self-referential thoughts (e.g. the default mode network) suggests that perceived stress may have a subtle impact on cognitive processing and neural correlates. |
| first_indexed | 2024-10-01T03:07:25Z |
| format | Journal Article |
| id | ntu-10356/85134 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:07:25Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/851342020-03-07T12:10:38Z Functional connectivity of resting-state, working memory and inhibition networks in perceived stress Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing Lee Kong Chian School of Medicine (LKCMedicine) School of Humanities and Social Sciences Centre for Research and Development in Learning (CRADLE) Functional magnetic resonance imaging Functional connectivity Perceived stress DRNTU::Science::Medicine Experimental imaging studies on the effects of acute stress have revealed functional changes in the amygdalae, hippocampi and medial frontal cortices. However, much less is known about the association between perceived stress and neurological function which may have implications for the development of stress related disorders. Participants completed a working-memory task and an inhibition task whilst undergoing a functional magnetic resonance imaging (fMRI) scan. Task related and resting-state fMRI data from 22 women and 24 men were analysed to investigate changes in task activations and functional connectivity associated with perceived stress over the past month. Analyses were stratified by gender due to gender differences in the stress response. Stress was associated with faster working memory response time in women, but not men. Stress was not associated with any differences in task activations in either gender. There were many significant associations between stress and connectivity: findings in women were consistent with increased emotional regulation; men exhibited decreases in connectivity between affective processing areas during the tasks and showed no relation between perceived stress and resting-state connectivity; very few of the within gender differences were significantly different between gender. Dysregulated connectivity between areas involved in the neural stress response and self-referential thoughts (e.g. the default mode network) suggests that perceived stress may have a subtle impact on cognitive processing and neural correlates. Published version 2017-08-29T02:16:39Z 2019-12-06T15:57:48Z 2017-08-29T02:16:39Z 2019-12-06T15:57:48Z 2017 Journal Article Archer, J. A., Lee, A., Qiu, A., & Annabel Chen, S. H. (2017). Functional connectivity of resting-state, working memory and inhibition networks in perceived stress. Neurobiology of Stress, 8, 186-201. doi: 10.1016/j.ynstr.2017.01.002. 2352-2895 https://hdl.handle.net/10356/85134 http://hdl.handle.net/10220/43645 10.1016/j.ynstr.2017.01.002 en Neurobiology of Stress © 2017 The Authors. Published by Elsevier Inc. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). 16 p. application/pdf |
| spellingShingle | Functional magnetic resonance imaging Functional connectivity Perceived stress DRNTU::Science::Medicine Archer, Jo A. Lee, Annie Qiu, Anqi Chen, Annabel Shen-Hsing Functional connectivity of resting-state, working memory and inhibition networks in perceived stress |
| title | Functional connectivity of resting-state, working memory and inhibition networks in perceived stress |
| title_full | Functional connectivity of resting-state, working memory and inhibition networks in perceived stress |
| title_fullStr | Functional connectivity of resting-state, working memory and inhibition networks in perceived stress |
| title_full_unstemmed | Functional connectivity of resting-state, working memory and inhibition networks in perceived stress |
| title_short | Functional connectivity of resting-state, working memory and inhibition networks in perceived stress |
| title_sort | functional connectivity of resting state working memory and inhibition networks in perceived stress |
| topic | Functional magnetic resonance imaging Functional connectivity Perceived stress DRNTU::Science::Medicine |
| url | https://hdl.handle.net/10356/85134 http://hdl.handle.net/10220/43645 |
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