Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes
Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes.
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/85142 http://hdl.handle.net/10220/43631 |
| _version_ | 1826126128763371520 |
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| author | Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve |
| author_sort | Lei, Chuanhu |
| collection | NTU |
| description | Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes. |
| first_indexed | 2024-10-01T06:47:39Z |
| format | Journal Article |
| id | ntu-10356/85142 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:47:39Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/851422023-02-28T19:22:32Z Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve School of Physical and Mathematical Sciences Palladium catalysis Ketone Palladium-catalyzed α-arylation reactions of ketones with simultaneous ortho alkylation offer 1,2,3-substituted arenes. The reactions of 1,ω-dihaloalkanes also allow facile construction of medicinally important tetralines and benzocycloheptenes. MOE (Min. of Education, S’pore) Accepted version 2017-08-25T05:19:54Z 2019-12-06T15:58:00Z 2017-08-25T05:19:54Z 2019-12-06T15:58:00Z 2016 Journal Article Lei, C., Cao, J., & Zhou, J. S. (2016). Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes. Organic Letters, 18(23), 6120-6123. 1523-7060 https://hdl.handle.net/10356/85142 http://hdl.handle.net/10220/43631 10.1021/acs.orglett.6b03130 en Organic Letters © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by Organic Letters, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acs.orglett.6b03130]. 5 p. application/pdf |
| spellingShingle | Palladium catalysis Ketone Lei, Chuanhu Cao, Jiajia Zhou, Jianrong Steve Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes |
| title | Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes |
| title_full | Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes |
| title_fullStr | Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes |
| title_full_unstemmed | Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes |
| title_short | Palladium-Catalyzed Arylation of Ketones and Acetonitrile with Ortho Alkylation of Aryl Rings: De Novo Synthesis of Tetralines and Benzocycloheptenes |
| title_sort | palladium catalyzed arylation of ketones and acetonitrile with ortho alkylation of aryl rings de novo synthesis of tetralines and benzocycloheptenes |
| topic | Palladium catalysis Ketone |
| url | https://hdl.handle.net/10356/85142 http://hdl.handle.net/10220/43631 |
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