Thrombogenic responses from electrocured tissue adhesives
Electrocured tissue adhesives offer a new route towards addressing unmet surgical challenges in tissue fixation. We have recently developed an electrocuring adhesive (aka Voltaglue) by grafting carbene precursors on polyamidoamine (PAMAM) G5 dendrimers. The cationic adhesive can be cured through low...
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/85359 http://hdl.handle.net/10220/48195 |
| _version_ | 1826114081257422848 |
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| author | Nanda, Himansu Sekhar Singh, Manisha Steele, Terry W. J. |
| author2 | School of Materials Science & Engineering |
| author_facet | School of Materials Science & Engineering Nanda, Himansu Sekhar Singh, Manisha Steele, Terry W. J. |
| author_sort | Nanda, Himansu Sekhar |
| collection | NTU |
| description | Electrocured tissue adhesives offer a new route towards addressing unmet surgical challenges in tissue fixation. We have recently developed an electrocuring adhesive (aka Voltaglue) by grafting carbene precursors on polyamidoamine (PAMAM) G5 dendrimers. The cationic adhesive can be cured through low-voltage activation and exhibits voltage and time dependent crosslinking, allowing some control over material and adhesive properties. Herein, we have evaluated the platelet adhesion and activation of the bioadhesives electrocured with applied voltages of 5V and 10V. The electrocured bioadhesives exhibited platelet resistant properties that was dependent on voltage magnitude. |
| first_indexed | 2024-10-01T03:33:40Z |
| format | Journal Article |
| id | ntu-10356/85359 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T03:33:40Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/853592023-07-14T15:45:40Z Thrombogenic responses from electrocured tissue adhesives Nanda, Himansu Sekhar Singh, Manisha Steele, Terry W. J. School of Materials Science & Engineering Interdisciplinary Graduate School (IGS) NTU-Northwestern Institute for Nanomedicine Adhesives Electrocured DRNTU::Engineering::Materials Electrocured tissue adhesives offer a new route towards addressing unmet surgical challenges in tissue fixation. We have recently developed an electrocuring adhesive (aka Voltaglue) by grafting carbene precursors on polyamidoamine (PAMAM) G5 dendrimers. The cationic adhesive can be cured through low-voltage activation and exhibits voltage and time dependent crosslinking, allowing some control over material and adhesive properties. Herein, we have evaluated the platelet adhesion and activation of the bioadhesives electrocured with applied voltages of 5V and 10V. The electrocured bioadhesives exhibited platelet resistant properties that was dependent on voltage magnitude. MOE (Min. of Education, S’pore) Published version 2019-05-14T09:24:29Z 2019-12-06T16:02:24Z 2019-05-14T09:24:29Z 2019-12-06T16:02:24Z 2017 Journal Article Nanda, H. S., Singh, M., & Steele, T. W. J. (2017). Thrombogenic responses from electrocured tissue adhesives. ECS Transactions, 77(11), 547-555. doi:10.1149/07711.0547ecst 1938-5862 https://hdl.handle.net/10356/85359 http://hdl.handle.net/10220/48195 10.1149/07711.0547ecst en ECS Transactions © 2017 The Electrochemical Society. All rights reserved. This paper was published in ECS Transactions and is made available with permission of The Electrochemical Society. 9 p. application/pdf |
| spellingShingle | Adhesives Electrocured DRNTU::Engineering::Materials Nanda, Himansu Sekhar Singh, Manisha Steele, Terry W. J. Thrombogenic responses from electrocured tissue adhesives |
| title | Thrombogenic responses from electrocured tissue adhesives |
| title_full | Thrombogenic responses from electrocured tissue adhesives |
| title_fullStr | Thrombogenic responses from electrocured tissue adhesives |
| title_full_unstemmed | Thrombogenic responses from electrocured tissue adhesives |
| title_short | Thrombogenic responses from electrocured tissue adhesives |
| title_sort | thrombogenic responses from electrocured tissue adhesives |
| topic | Adhesives Electrocured DRNTU::Engineering::Materials |
| url | https://hdl.handle.net/10356/85359 http://hdl.handle.net/10220/48195 |
| work_keys_str_mv | AT nandahimansusekhar thrombogenicresponsesfromelectrocuredtissueadhesives AT singhmanisha thrombogenicresponsesfromelectrocuredtissueadhesives AT steeleterrywj thrombogenicresponsesfromelectrocuredtissueadhesives |