Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser
Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80–180 nm have been synthesized through a facile, controllabl...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
| Published: |
2019
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| Online Access: | https://hdl.handle.net/10356/85402 http://hdl.handle.net/10220/48219 |
| _version_ | 1826129783611719680 |
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| author | Liu, Bei Li, Chunxia Chen, Guanying Liu, Bin Deng, Xiaoran Wei, Yi Xia, Jun Xing, Bengang Ma, Ping'an Lin, Jun |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Liu, Bei Li, Chunxia Chen, Guanying Liu, Bin Deng, Xiaoran Wei, Yi Xia, Jun Xing, Bengang Ma, Ping'an Lin, Jun |
| author_sort | Liu, Bei |
| collection | NTU |
| description | Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80–180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS2 nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS2@Fe3O4‐ICG/Pt(IV) (labeled as Mo@Fe‐ICG/Pt) is designed by covalently grafting Fe3O4 nanoparticles with polyethylenimine (PEI) functionalized MoS2, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS2@Fe3O4. The resulting Mo@Fe‐ICG/Pt nanocomposites can achieve excellent magnetic resonance/infrared thermal/photoacoustic trimodal biomaging as well as remarkably enhanced antitumor efficacy of combined photothermal therapy, photodynamic therapy, and chemotherapy triggered by a single 808 nm NIR laser, thus leading to an ideal nanoplatform for cancer diagnosis and treatment in future. |
| first_indexed | 2024-10-01T07:46:12Z |
| format | Journal Article |
| id | ntu-10356/85402 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:46:12Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/854022023-02-28T19:22:40Z Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser Liu, Bei Li, Chunxia Chen, Guanying Liu, Bin Deng, Xiaoran Wei, Yi Xia, Jun Xing, Bengang Ma, Ping'an Lin, Jun School of Physical and Mathematical Sciences 808 nm Bioimaging DRNTU::Science::Chemistry Elaborately designed biocompatible nanoplatforms simultaneously achieving multimodal bioimaging and therapeutic functions are highly desirable for modern biomedical applications. Herein, uniform MoS2 nanoflowers with a broad size range of 80–180 nm have been synthesized through a facile, controllable, and scalable hydrothermal method. The strong absorbance of MoS2 nanoflowers at 808 nm imparts them with high efficiency and stability of photothermal conversion. Then a novel multifunctional composite of MoS2@Fe3O4‐ICG/Pt(IV) (labeled as Mo@Fe‐ICG/Pt) is designed by covalently grafting Fe3O4 nanoparticles with polyethylenimine (PEI) functionalized MoS2, and then loading indocyanine green molecules (ICG, photosensitizers) and platinum (IV) prodrugs (labeled as Pt(IV) prodrugs) on the surface of MoS2@Fe3O4. The resulting Mo@Fe‐ICG/Pt nanocomposites can achieve excellent magnetic resonance/infrared thermal/photoacoustic trimodal biomaging as well as remarkably enhanced antitumor efficacy of combined photothermal therapy, photodynamic therapy, and chemotherapy triggered by a single 808 nm NIR laser, thus leading to an ideal nanoplatform for cancer diagnosis and treatment in future. Published version 2019-05-16T02:49:58Z 2019-12-06T16:03:05Z 2019-05-16T02:49:58Z 2019-12-06T16:03:05Z 2017 Journal Article Liu, B., Li, C., Chen, G., Liu, B., Deng, X., Wei, Y., . . . Lin, J. (2017). Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser. Advanced Science, 4(8), 1600540-. doi:10.1002/advs.201600540 https://hdl.handle.net/10356/85402 http://hdl.handle.net/10220/48219 10.1002/advs.201600540 en Advanced Science © 2017 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. 12 p. application/pdf |
| spellingShingle | 808 nm Bioimaging DRNTU::Science::Chemistry Liu, Bei Li, Chunxia Chen, Guanying Liu, Bin Deng, Xiaoran Wei, Yi Xia, Jun Xing, Bengang Ma, Ping'an Lin, Jun Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser |
| title | Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser |
| title_full | Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser |
| title_fullStr | Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser |
| title_full_unstemmed | Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser |
| title_short | Synthesis and optimization of MoS2@Fe3O4-ICG/Pt(IV) nanoflowers for MR/IR/PA bioimaging and combined PTT/PDT/Chemotherapy triggered by 808 nm laser |
| title_sort | synthesis and optimization of mos2 fe3o4 icg pt iv nanoflowers for mr ir pa bioimaging and combined ptt pdt chemotherapy triggered by 808 nm laser |
| topic | 808 nm Bioimaging DRNTU::Science::Chemistry |
| url | https://hdl.handle.net/10356/85402 http://hdl.handle.net/10220/48219 |
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