Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect
Near-infrared (NIR) light-responsive hydrogels are important for biomedical applications, such as remote-controlled release, but the NIR agents previously used were largely limited to heavy-metal inorganic materials such as gold nanoparticles. In this article, we report a new type of NIR phototherma...
| Main Authors: | , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/85465 http://hdl.handle.net/10220/43724 |
| _version_ | 1826117724262105088 |
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| author | Wu, Yingjie Wang, Kai Huang, Shuo Yang, Cangjie Wang, Mingfeng |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Wu, Yingjie Wang, Kai Huang, Shuo Yang, Cangjie Wang, Mingfeng |
| author_sort | Wu, Yingjie |
| collection | NTU |
| description | Near-infrared (NIR) light-responsive hydrogels are important for biomedical applications, such as remote-controlled release, but the NIR agents previously used were largely limited to heavy-metal inorganic materials such as gold nanoparticles. In this article, we report a new type of NIR photothermal-responsive hydrogel that can undergo structural changes in response to NIR light for biomedical applications in drug delivery and controlled release. The hydrogels synthesized by integrating a narrow-bandgap semiconductor polymer poly(diketopyrrolopyrrole-alt-3,4-ethylenedioxythiophene) with the polymerization of N-isopropylacrylamide show rapid and reversible mechanical shrinkage upon NIR light irradiation and can serve as carriers for anticancer drug loading and spatial/temporal control of drug release. These stimuli-responsive hydrogels, which can be prepared in different sizes and shapes, integrate photothermal properties and hydrogel characteristics and can provide on-demand, repeated, remote-controlled drug delivery for biomedical applications such as cancer treatment. |
| first_indexed | 2024-10-01T04:31:58Z |
| format | Journal Article |
| id | ntu-10356/85465 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T04:31:58Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/854652023-12-29T06:47:53Z Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect Wu, Yingjie Wang, Kai Huang, Shuo Yang, Cangjie Wang, Mingfeng School of Chemical and Biomedical Engineering Controlled Release Drug Delivery Near-infrared (NIR) light-responsive hydrogels are important for biomedical applications, such as remote-controlled release, but the NIR agents previously used were largely limited to heavy-metal inorganic materials such as gold nanoparticles. In this article, we report a new type of NIR photothermal-responsive hydrogel that can undergo structural changes in response to NIR light for biomedical applications in drug delivery and controlled release. The hydrogels synthesized by integrating a narrow-bandgap semiconductor polymer poly(diketopyrrolopyrrole-alt-3,4-ethylenedioxythiophene) with the polymerization of N-isopropylacrylamide show rapid and reversible mechanical shrinkage upon NIR light irradiation and can serve as carriers for anticancer drug loading and spatial/temporal control of drug release. These stimuli-responsive hydrogels, which can be prepared in different sizes and shapes, integrate photothermal properties and hydrogel characteristics and can provide on-demand, repeated, remote-controlled drug delivery for biomedical applications such as cancer treatment. MOE (Min. of Education, S’pore) Accepted version 2017-09-12T04:23:48Z 2019-12-06T16:04:12Z 2017-09-12T04:23:48Z 2019-12-06T16:04:12Z 2017 Journal Article Wu, Y., Wang, K., Huang, S., Yang, C., & Wang, M. (2017). Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect. ACS Applied Materials & Interfaces, 9(15), 13602-13610. 1944-8244 https://hdl.handle.net/10356/85465 http://hdl.handle.net/10220/43724 10.1021/acsami.7b01016 en ACS Applied Materials & Interfaces © 2017 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Applied Materials & Interfaces, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acsami.7b01016]. 31 p. application/pdf |
| spellingShingle | Controlled Release Drug Delivery Wu, Yingjie Wang, Kai Huang, Shuo Yang, Cangjie Wang, Mingfeng Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect |
| title | Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect |
| title_full | Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect |
| title_fullStr | Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect |
| title_full_unstemmed | Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect |
| title_short | Near-Infrared Light-Responsive Semiconductor Polymer Composite Hydrogels: Spatial/Temporal-Controlled Release via a Photothermal “Sponge” Effect |
| title_sort | near infrared light responsive semiconductor polymer composite hydrogels spatial temporal controlled release via a photothermal sponge effect |
| topic | Controlled Release Drug Delivery |
| url | https://hdl.handle.net/10356/85465 http://hdl.handle.net/10220/43724 |
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