Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols
A carbene-catalyzed desymmetrization of prochiral bisphenol compounds bearing remote P-stereogenic centers is disclosed. The catalytic reactions can be performed on gram scales with 1 mol % N-heterocyclic carbene (NHC) catalyst, providing efficient access to enantiomerically enriched P-stereogenic p...
| Main Authors: | , , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2017
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/85621 http://hdl.handle.net/10220/43779 |
| _version_ | 1826124267974033408 |
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| author | Huang, Zhijian Huang, Xuan Li, Baosheng Mou, Chengli Yang, Song Song, Bao-An Chi, Yonggui Robin |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences Huang, Zhijian Huang, Xuan Li, Baosheng Mou, Chengli Yang, Song Song, Bao-An Chi, Yonggui Robin |
| author_sort | Huang, Zhijian |
| collection | NTU |
| description | A carbene-catalyzed desymmetrization of prochiral bisphenol compounds bearing remote P-stereogenic centers is disclosed. The catalytic reactions can be performed on gram scales with 1 mol % N-heterocyclic carbene (NHC) catalyst, providing efficient access to enantiomerically enriched P-stereogenic phosphinates. The chiral phosphinates prepared with our method can find widespread applications as asymmetric organic catalysts and ligands. |
| first_indexed | 2024-10-01T06:17:52Z |
| format | Journal Article |
| id | ntu-10356/85621 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:17:52Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/856212020-03-07T12:31:32Z Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols Huang, Zhijian Huang, Xuan Li, Baosheng Mou, Chengli Yang, Song Song, Bao-An Chi, Yonggui Robin School of Physical and Mathematical Sciences Bisphenols Phosphinates A carbene-catalyzed desymmetrization of prochiral bisphenol compounds bearing remote P-stereogenic centers is disclosed. The catalytic reactions can be performed on gram scales with 1 mol % N-heterocyclic carbene (NHC) catalyst, providing efficient access to enantiomerically enriched P-stereogenic phosphinates. The chiral phosphinates prepared with our method can find widespread applications as asymmetric organic catalysts and ligands. MOE (Min. of Education, S’pore) 2017-09-22T03:46:12Z 2019-12-06T16:07:14Z 2017-09-22T03:46:12Z 2019-12-06T16:07:14Z 2016 Journal Article Huang, Z., Huang, X., Li, B., Mou, C., Yang, S., Song, B.-A., et al. (2016). Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols. Journal of the American Chemical Society, 138(24), 7524-7527. 0002-7863 https://hdl.handle.net/10356/85621 http://hdl.handle.net/10220/43779 10.1021/jacs.6b04624 en Journal of the American Chemical Society © 2016 American Chemical Society |
| spellingShingle | Bisphenols Phosphinates Huang, Zhijian Huang, Xuan Li, Baosheng Mou, Chengli Yang, Song Song, Bao-An Chi, Yonggui Robin Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols |
| title | Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols |
| title_full | Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols |
| title_fullStr | Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols |
| title_full_unstemmed | Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols |
| title_short | Access to P-Stereogenic Phosphinates via N-Heterocyclic Carbene-Catalyzed Desymmetrization of Bisphenols |
| title_sort | access to p stereogenic phosphinates via n heterocyclic carbene catalyzed desymmetrization of bisphenols |
| topic | Bisphenols Phosphinates |
| url | https://hdl.handle.net/10356/85621 http://hdl.handle.net/10220/43779 |
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