Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective
Arbovirus transmission is modulated by host, vector, virus, and environmental factors. Even though viral fitness plays a salient role in host and vector adaptation, the transmission success of individual strains in a heterogeneous population may be stochastic. Our large-scale molecular epidemiologic...
| Main Authors: | , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/85711 http://hdl.handle.net/10220/49841 |
| _version_ | 1811693615016050688 |
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| author | Koo, Carmen Tien, Wei Ping Xu, Helen Ong, Janet Rajarethinam, Jayanthi Lai, Yee Ling Ng, Lee-Ching Hapuarachchi, Hapuarachchige Chanditha |
| author2 | School of Biological Sciences |
| author_facet | School of Biological Sciences Koo, Carmen Tien, Wei Ping Xu, Helen Ong, Janet Rajarethinam, Jayanthi Lai, Yee Ling Ng, Lee-Ching Hapuarachchi, Hapuarachchige Chanditha |
| author_sort | Koo, Carmen |
| collection | NTU |
| description | Arbovirus transmission is modulated by host, vector, virus, and environmental factors. Even though viral fitness plays a salient role in host and vector adaptation, the transmission success of individual strains in a heterogeneous population may be stochastic. Our large-scale molecular epidemiological analyses of a dengue virus type 1 population revealed that only a subset of strains (16.7%; n = 6) were able to sustain transmission, despite the population being widely dispersed, dynamic, and heterogeneous. The overall dominance was variable even among the “established” lineages, albeit sharing comparable evolutionary characteristics and replication profiles. These findings indicated that virological parameters alone were unlikely to have a profound effect on the survival of viral lineages, suggesting an important role for non-viral factors in the transmission success of lineages. Our observations, therefore, emphasize the strategic importance of a holistic understanding of vector, human host, and viral factors in the control of vector-borne diseases. |
| first_indexed | 2024-10-01T06:54:29Z |
| format | Journal Article |
| id | ntu-10356/85711 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:54:29Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/857112023-02-28T17:01:12Z Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective Koo, Carmen Tien, Wei Ping Xu, Helen Ong, Janet Rajarethinam, Jayanthi Lai, Yee Ling Ng, Lee-Ching Hapuarachchi, Hapuarachchige Chanditha School of Biological Sciences Disease Virology Science::Biological sciences Arbovirus transmission is modulated by host, vector, virus, and environmental factors. Even though viral fitness plays a salient role in host and vector adaptation, the transmission success of individual strains in a heterogeneous population may be stochastic. Our large-scale molecular epidemiological analyses of a dengue virus type 1 population revealed that only a subset of strains (16.7%; n = 6) were able to sustain transmission, despite the population being widely dispersed, dynamic, and heterogeneous. The overall dominance was variable even among the “established” lineages, albeit sharing comparable evolutionary characteristics and replication profiles. These findings indicated that virological parameters alone were unlikely to have a profound effect on the survival of viral lineages, suggesting an important role for non-viral factors in the transmission success of lineages. Our observations, therefore, emphasize the strategic importance of a holistic understanding of vector, human host, and viral factors in the control of vector-borne diseases. Published version 2019-09-03T03:12:02Z 2019-12-06T16:08:50Z 2019-09-03T03:12:02Z 2019-12-06T16:08:50Z 2018 Journal Article Koo, C., Tien, W. P., Xu, H., Ong, J., Rajarethinam, J., Lai, Y. L., . . . Hapuarachchi, H. C. (2018). Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective. iScience, 6, 38-51. doi:10.1016/j.isci.2018.07.008 https://hdl.handle.net/10356/85711 http://hdl.handle.net/10220/49841 10.1016/j.isci.2018.07.008 en iScience © 2018 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). 27 p. application/pdf |
| spellingShingle | Disease Virology Science::Biological sciences Koo, Carmen Tien, Wei Ping Xu, Helen Ong, Janet Rajarethinam, Jayanthi Lai, Yee Ling Ng, Lee-Ching Hapuarachchi, Hapuarachchige Chanditha Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective |
| title | Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective |
| title_full | Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective |
| title_fullStr | Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective |
| title_full_unstemmed | Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective |
| title_short | Highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population : an evolutionary and fitness perspective |
| title_sort | highly selective transmission success of dengue virus type 1 lineages in a dynamic virus population an evolutionary and fitness perspective |
| topic | Disease Virology Science::Biological sciences |
| url | https://hdl.handle.net/10356/85711 http://hdl.handle.net/10220/49841 |
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