Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders
Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with earl...
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| Format: | Journal Article |
| Language: | English |
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2017
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| Online Access: | https://hdl.handle.net/10356/86083 http://hdl.handle.net/10220/43938 https://www.sciencedirect.com/science/article/pii/S0891422217302524 |
| _version_ | 1826128355983884288 |
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| author | Cataldo, Ilaria Azhari, Atiqah Lepri, Bruno Esposito, Gianluca |
| author2 | School of Humanities and Social Sciences |
| author_facet | School of Humanities and Social Sciences Cataldo, Ilaria Azhari, Atiqah Lepri, Bruno Esposito, Gianluca |
| author_sort | Cataldo, Ilaria |
| collection | NTU |
| description | Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword “OXTR” before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total. The papers were catalogued in a database and filtered for gene-environment interaction, psychiatric disorders and involvement of parental care. In particular, rs53576 and rs2254298 were found to be significantly involved in gene-environment interactions that modulated risk for psychopathology and the following psychiatric disorders: disruptive behavior, depression, anxiety, eating disorder and borderline personality disorder. These results illustrate the importance of OXTR in mediating the impact of parental care on the emergence of psychopathology. |
| first_indexed | 2024-10-01T07:23:39Z |
| format | Journal Article |
| id | ntu-10356/86083 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:23:39Z |
| publishDate | 2017 |
| record_format | dspace |
| spelling | ntu-10356/860832020-03-07T12:10:38Z Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders Cataldo, Ilaria Azhari, Atiqah Lepri, Bruno Esposito, Gianluca School of Humanities and Social Sciences Gene-environment interaction OXTR Oxytocin plays an important role in the modulation of social behavior in both typical and atypical contexts. Also, the quality of early parental care sets the foundation for long-term psychosocial development. Here, we review studies that investigated how oxytocin receptor (OXTR) interacts with early parental care experiences to influence the development of psychiatric disorders. Using Pubmed, Scopus and PsycInfo databases, we utilized the keyword “OXTR” before subsequently searching for specific OXTR single nucleotide polymorphisms (SNPs), generating a list of 598 studies in total. The papers were catalogued in a database and filtered for gene-environment interaction, psychiatric disorders and involvement of parental care. In particular, rs53576 and rs2254298 were found to be significantly involved in gene-environment interactions that modulated risk for psychopathology and the following psychiatric disorders: disruptive behavior, depression, anxiety, eating disorder and borderline personality disorder. These results illustrate the importance of OXTR in mediating the impact of parental care on the emergence of psychopathology. Accepted version 2017-10-23T03:01:10Z 2019-12-06T16:15:39Z 2017-10-23T03:01:10Z 2019-12-06T16:15:39Z 2017 Journal Article Cataldo, I., Azhari, A., Lepri, B., & Esposito, G. (2017). Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders. Research in Developmental Disabilities, in press. 0891-4222 https://hdl.handle.net/10356/86083 http://hdl.handle.net/10220/43938 10.1016/j.ridd.2017.10.007 https://www.sciencedirect.com/science/article/pii/S0891422217302524 en Research in Developmental Disabilities © 2017 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Research in Developmental Disabilities, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.ridd.2017.10.007]. 27 p. application/pdf |
| spellingShingle | Gene-environment interaction OXTR Cataldo, Ilaria Azhari, Atiqah Lepri, Bruno Esposito, Gianluca Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders |
| title | Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders |
| title_full | Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders |
| title_fullStr | Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders |
| title_full_unstemmed | Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders |
| title_short | Oxytocin receptors (OXTR) and early parental care: An interaction that modulates psychiatric disorders |
| title_sort | oxytocin receptors oxtr and early parental care an interaction that modulates psychiatric disorders |
| topic | Gene-environment interaction OXTR |
| url | https://hdl.handle.net/10356/86083 http://hdl.handle.net/10220/43938 https://www.sciencedirect.com/science/article/pii/S0891422217302524 |
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