Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior
Impulsivity is closely associated with addictive disorders, and changes in the brain dopamine system have been proposed to affect impulse control in reward-related behaviors. However, the central neural pathways through which the dopamine system controls impulsive behavior are still unclear. We foun...
| Main Authors: | , , , , , , , , , |
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| Format: | Journal Article |
| Language: | English |
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2019
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| Online Access: | https://hdl.handle.net/10356/86085 http://hdl.handle.net/10220/49852 |
| _version_ | 1811693554065473536 |
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| author | Kim, Bokyeong Yoon, Sehyoun Nakajima, Ryuichi Lee, Hyo Jin Lim, Hee Jeong Lee, Yeon-Kyung Choi, June-Seek Yoon, Bong-June Augustine, George James Baik, Ja-Hyun |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Kim, Bokyeong Yoon, Sehyoun Nakajima, Ryuichi Lee, Hyo Jin Lim, Hee Jeong Lee, Yeon-Kyung Choi, June-Seek Yoon, Bong-June Augustine, George James Baik, Ja-Hyun |
| author_sort | Kim, Bokyeong |
| collection | NTU |
| description | Impulsivity is closely associated with addictive disorders, and changes in the brain dopamine system have been proposed to affect impulse control in reward-related behaviors. However, the central neural pathways through which the dopamine system controls impulsive behavior are still unclear. We found that the absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala (CeA) of D2R knockout mice (Drd2−/−) normalized their enhanced impulsivity. Inhibitory synaptic output from D2R-expressing neurons in the CeA underlies modulation of impulsive behavior because optogenetic activation of D2R-positive inhibitory neurons that project from the CeA to the bed nucleus of the stria terminalis (BNST) attenuate such behavior. Our identification of the key contribution of D2R-expressing neurons in the CeA → BNST circuit to the control of impulsive behavior reveals a pathway that could serve as a target for approaches to the management of neuropsychiatric disorders associated with impulsivity. |
| first_indexed | 2024-10-01T06:53:31Z |
| format | Journal Article |
| id | ntu-10356/86085 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:53:31Z |
| publishDate | 2019 |
| record_format | dspace |
| spelling | ntu-10356/860852020-11-01T05:25:56Z Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior Kim, Bokyeong Yoon, Sehyoun Nakajima, Ryuichi Lee, Hyo Jin Lim, Hee Jeong Lee, Yeon-Kyung Choi, June-Seek Yoon, Bong-June Augustine, George James Baik, Ja-Hyun Lee Kong Chian School of Medicine (LKCMedicine) Dopamine Receptor Impulsivity Science::Biological sciences::Human anatomy and physiology::Neurobiology Impulsivity is closely associated with addictive disorders, and changes in the brain dopamine system have been proposed to affect impulse control in reward-related behaviors. However, the central neural pathways through which the dopamine system controls impulsive behavior are still unclear. We found that the absence of the D2 dopamine receptor (D2R) increased impulsive behavior in mice, whereas restoration of D2R expression specifically in the central amygdala (CeA) of D2R knockout mice (Drd2−/−) normalized their enhanced impulsivity. Inhibitory synaptic output from D2R-expressing neurons in the CeA underlies modulation of impulsive behavior because optogenetic activation of D2R-positive inhibitory neurons that project from the CeA to the bed nucleus of the stria terminalis (BNST) attenuate such behavior. Our identification of the key contribution of D2R-expressing neurons in the CeA → BNST circuit to the control of impulsive behavior reveals a pathway that could serve as a target for approaches to the management of neuropsychiatric disorders associated with impulsivity. MOE (Min. of Education, S’pore) Published version 2019-09-04T02:10:46Z 2019-12-06T16:15:41Z 2019-09-04T02:10:46Z 2019-12-06T16:15:41Z 2018 Journal Article Kim, B., Yoon, S., Nakajima, R., Lee, H. J., Lim, H. J., Lee, Y.-K., . . . Baik, J.-H. (2018). Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior. Proceedings of the National Academy of Sciences, 115(45), E10730-E10739. doi:10.1073/pnas.1811664115 0027-8424 https://hdl.handle.net/10356/86085 http://hdl.handle.net/10220/49852 10.1073/pnas.1811664115 en Proceedings of the National Academy of Sciences © 2018 The Author(s). Published by PNAS. This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND). 10 p. application/pdf |
| spellingShingle | Dopamine Receptor Impulsivity Science::Biological sciences::Human anatomy and physiology::Neurobiology Kim, Bokyeong Yoon, Sehyoun Nakajima, Ryuichi Lee, Hyo Jin Lim, Hee Jeong Lee, Yeon-Kyung Choi, June-Seek Yoon, Bong-June Augustine, George James Baik, Ja-Hyun Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| title | Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| title_full | Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| title_fullStr | Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| title_full_unstemmed | Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| title_short | Dopamine D2 receptor-mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| title_sort | dopamine d2 receptor mediated circuit from the central amygdala to the bed nucleus of the stria terminalis regulates impulsive behavior |
| topic | Dopamine Receptor Impulsivity Science::Biological sciences::Human anatomy and physiology::Neurobiology |
| url | https://hdl.handle.net/10356/86085 http://hdl.handle.net/10220/49852 |
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