3D neural tissue models : from spheroids to bioprinting
Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studi...
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/86209 http://hdl.handle.net/10220/46697 |
| _version_ | 1811693594793213952 |
|---|---|
| author | Zhuang, Pei Sun, Alfred Xuyang An, Jia Chua, Chee Kai Chew, Sing Yian |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Zhuang, Pei Sun, Alfred Xuyang An, Jia Chua, Chee Kai Chew, Sing Yian |
| author_sort | Zhuang, Pei |
| collection | NTU |
| description | Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications. Bioprinting offers a revolutionary approach for constructing repeatable and controllable 3D in vitro neural tissues with diverse cell types, complex microscale features and tissue level responses. Further advances in bioprinting research would likely consolidate existing models and generate complex neural tissue structures bearing higher fidelity, which is ultimately useful for probing disease-specific mechanisms, facilitating development of novel therapeutics and promoting neural regeneration. |
| first_indexed | 2024-10-01T06:54:10Z |
| format | Journal Article |
| id | ntu-10356/86209 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:54:10Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/862092020-11-01T05:25:57Z 3D neural tissue models : from spheroids to bioprinting Zhuang, Pei Sun, Alfred Xuyang An, Jia Chua, Chee Kai Chew, Sing Yian School of Chemical and Biomedical Engineering School of Mechanical and Aerospace Engineering Lee Kong Chian School of Medicine (LKCMedicine) A*STAR Genome Institute of Singapore Singapore Centre for 3D Printing 3D Printing Nerve Regeneration DRNTU::Engineering::Mechanical engineering Three-dimensional (3D) in vitro neural tissue models provide a better recapitulation of in vivo cell-cell and cell-extracellular matrix interactions than conventional two-dimensional (2D) cultures. Therefore, the former is believed to have great potential for both mechanistic and translational studies. In this paper, we review the recent developments in 3D in vitro neural tissue models, with a particular focus on the emerging bioprinted tissue structures. We draw on specific examples to describe the merits and limitations of each model, in terms of different applications. Bioprinting offers a revolutionary approach for constructing repeatable and controllable 3D in vitro neural tissues with diverse cell types, complex microscale features and tissue level responses. Further advances in bioprinting research would likely consolidate existing models and generate complex neural tissue structures bearing higher fidelity, which is ultimately useful for probing disease-specific mechanisms, facilitating development of novel therapeutics and promoting neural regeneration. NRF (Natl Research Foundation, S’pore) Accepted version 2018-11-26T01:58:48Z 2019-12-06T16:18:06Z 2018-11-26T01:58:48Z 2019-12-06T16:18:06Z 2018 Journal Article Zhuang, P., Sun, A. X., An, J., Chua, C. K., & Chew, S. Y. (2018). 3D neural tissue models : from spheroids to bioprinting. Biomaterials, 154113-133. doi:10.1016/j.biomaterials.2017.10.002 0142-9612 https://hdl.handle.net/10356/86209 http://hdl.handle.net/10220/46697 10.1016/j.biomaterials.2017.10.002 en Biomaterials © 2018 Elsevier. This is the author created version of a work that has been peer reviewed and accepted for publication by Biomaterials, Elsevier. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.biomaterials.2017.10.002]. 52 p. application/pdf |
| spellingShingle | 3D Printing Nerve Regeneration DRNTU::Engineering::Mechanical engineering Zhuang, Pei Sun, Alfred Xuyang An, Jia Chua, Chee Kai Chew, Sing Yian 3D neural tissue models : from spheroids to bioprinting |
| title | 3D neural tissue models : from spheroids to bioprinting |
| title_full | 3D neural tissue models : from spheroids to bioprinting |
| title_fullStr | 3D neural tissue models : from spheroids to bioprinting |
| title_full_unstemmed | 3D neural tissue models : from spheroids to bioprinting |
| title_short | 3D neural tissue models : from spheroids to bioprinting |
| title_sort | 3d neural tissue models from spheroids to bioprinting |
| topic | 3D Printing Nerve Regeneration DRNTU::Engineering::Mechanical engineering |
| url | https://hdl.handle.net/10356/86209 http://hdl.handle.net/10220/46697 |
| work_keys_str_mv | AT zhuangpei 3dneuraltissuemodelsfromspheroidstobioprinting AT sunalfredxuyang 3dneuraltissuemodelsfromspheroidstobioprinting AT anjia 3dneuraltissuemodelsfromspheroidstobioprinting AT chuacheekai 3dneuraltissuemodelsfromspheroidstobioprinting AT chewsingyian 3dneuraltissuemodelsfromspheroidstobioprinting |