Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities

Chikungunya virus nsP4 RNA-dependent RNA polymerase core domain displays detergent-sensitive primer extension and terminal adenylyltransferase activities

Chikungunya virus (CHIKV) is an important arboviral infectious agent in tropical and subtropical regions, often causing persistent and debilitating disease. The viral enzyme non-structural protein 4 (nsP4), as RNA-dependent RNA polymerase (RdRP), catalyzes the formation of negative-sense, genomic an...

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Bibliographic Details
Main Authors: Chen, Ming Wei, Tan, Yaw Bia, Zheng, Jie, Zhao, Yongqian, Lim, Bee Ting, Cornvik, Tobias, Lescar, Julien, Ng, Lisa Fong Poh, Luo, Dahai
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Journal Article
Language:English
Published: 2017
Subjects:
Chikungunya
RdRP
Online Access:https://hdl.handle.net/10356/86660
http://hdl.handle.net/10220/44135

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