Macrophage–Bacteria Interactions—A Lipid-Centric Relationship
Macrophages are professional phagocytes at the front line of immune defenses against foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly diseases including tuberculosis and salmonellosis, are capable of hijacking this important immune cell type and thrive intra...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/87032 http://hdl.handle.net/10220/44282 |
| _version_ | 1811695923322945536 |
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| author | Teng, Ooiean Ang, Candice Ke En Guan, Xue Li |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Teng, Ooiean Ang, Candice Ke En Guan, Xue Li |
| author_sort | Teng, Ooiean |
| collection | NTU |
| description | Macrophages are professional phagocytes at the front line of immune defenses against foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly diseases including tuberculosis and salmonellosis, are capable of hijacking this important immune cell type and thrive intracellularly, either in the cytoplasm or in specialized vacuoles. Tight regulation of cellular metabolism is critical in shaping the macrophage polarization states and immune functions. Lipids, besides being the bulk component of biological membranes, serve as energy sources as well as signaling molecules during infection and inflammation. With the advent of systems-scale analyses of genes, transcripts, proteins, and metabolites, in combination with classical biology, it is increasingly evident that macrophages undergo extensive lipid remodeling during activation and infection. Each bacterium species has evolved its own tactics to manipulate host metabolism toward its own advantage. Furthermore, modulation of host lipid metabolism affects disease susceptibility and outcome of infections, highlighting the critical roles of lipids in infectious diseases. Here, we will review the emerging roles of lipids in the complex host–pathogen relationship and discuss recent methodologies employed to probe these versatile metabolites during the infection process. An improved understanding of the lipid-centric nature of infections can lead to the identification of the Achilles’ heel of the pathogens and host-directed targets for therapeutic interventions. Currently, lipid-moderating drugs are clinically available for a range of non-communicable diseases, which we anticipate can potentially be tapped into for various infections. |
| first_indexed | 2024-10-01T07:31:11Z |
| format | Journal Article |
| id | ntu-10356/87032 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:31:11Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/870322020-11-01T05:28:14Z Macrophage–Bacteria Interactions—A Lipid-Centric Relationship Teng, Ooiean Ang, Candice Ke En Guan, Xue Li Lee Kong Chian School of Medicine (LKCMedicine) Lipids Metabolism Macrophages are professional phagocytes at the front line of immune defenses against foreign bodies and microbial pathogens. Various bacteria, which are responsible for deadly diseases including tuberculosis and salmonellosis, are capable of hijacking this important immune cell type and thrive intracellularly, either in the cytoplasm or in specialized vacuoles. Tight regulation of cellular metabolism is critical in shaping the macrophage polarization states and immune functions. Lipids, besides being the bulk component of biological membranes, serve as energy sources as well as signaling molecules during infection and inflammation. With the advent of systems-scale analyses of genes, transcripts, proteins, and metabolites, in combination with classical biology, it is increasingly evident that macrophages undergo extensive lipid remodeling during activation and infection. Each bacterium species has evolved its own tactics to manipulate host metabolism toward its own advantage. Furthermore, modulation of host lipid metabolism affects disease susceptibility and outcome of infections, highlighting the critical roles of lipids in infectious diseases. Here, we will review the emerging roles of lipids in the complex host–pathogen relationship and discuss recent methodologies employed to probe these versatile metabolites during the infection process. An improved understanding of the lipid-centric nature of infections can lead to the identification of the Achilles’ heel of the pathogens and host-directed targets for therapeutic interventions. Currently, lipid-moderating drugs are clinically available for a range of non-communicable diseases, which we anticipate can potentially be tapped into for various infections. MOE (Min. of Education, S’pore) Published version 2018-01-09T05:36:12Z 2019-12-06T16:33:33Z 2018-01-09T05:36:12Z 2019-12-06T16:33:33Z 2017 Journal Article Teng, O., Ang, C. K. E., & Guan, X. L. (2017). Macrophage–Bacteria Interactions—A Lipid-Centric Relationship. Frontiers in Immunology, 8, 1836-. https://hdl.handle.net/10356/87032 http://hdl.handle.net/10220/44282 10.3389/fimmu.2017.01836 en Frontiers in Immunology © 2017 Teng, Ang and Guan. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 17 p. application/pdf |
| spellingShingle | Lipids Metabolism Teng, Ooiean Ang, Candice Ke En Guan, Xue Li Macrophage–Bacteria Interactions—A Lipid-Centric Relationship |
| title | Macrophage–Bacteria Interactions—A Lipid-Centric Relationship |
| title_full | Macrophage–Bacteria Interactions—A Lipid-Centric Relationship |
| title_fullStr | Macrophage–Bacteria Interactions—A Lipid-Centric Relationship |
| title_full_unstemmed | Macrophage–Bacteria Interactions—A Lipid-Centric Relationship |
| title_short | Macrophage–Bacteria Interactions—A Lipid-Centric Relationship |
| title_sort | macrophage bacteria interactions a lipid centric relationship |
| topic | Lipids Metabolism |
| url | https://hdl.handle.net/10356/87032 http://hdl.handle.net/10220/44282 |
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