Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations
The oxytocinergic system is highly involved in social bonding and early caregiver–infant interactions. Here, we hypothesize that oxytocin receptor (OXTR) gene genotype and parental bonding history interact in influencing social development. To address this question, we assessed adult males’ arousal...
| Main Authors: | , , , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/87243 http://hdl.handle.net/10220/44341 |
| _version_ | 1826110239887327232 |
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| author | Truzzi, Anna Poquérusse, Jessie Setoh, Peipei Shinohara, Kazuyuki Bornstein, Marc H. Esposito, Gianluca |
| author2 | School of Humanities and Social Sciences |
| author_facet | School of Humanities and Social Sciences Truzzi, Anna Poquérusse, Jessie Setoh, Peipei Shinohara, Kazuyuki Bornstein, Marc H. Esposito, Gianluca |
| author_sort | Truzzi, Anna |
| collection | NTU |
| description | The oxytocinergic system is highly involved in social bonding and early caregiver–infant interactions. Here, we hypothesize that oxytocin receptor (OXTR) gene genotype and parental bonding history interact in influencing social development. To address this question, we assessed adult males’ arousal (heart rate changes) in response to different distress vocalizations (human female, human infant and bonobo). Region rs53576 of the OXTR gene was genotyped from buccal mucosa cell samples, and a self-report Parental Bonding Instrument was used (which provide information about parental care or parental overprotection). A significant gene–environment interaction between OXTR genotype and parenting style was found to influence participants’ social responsivity to female cry vocalizations. Specifically, a history of appropriate paternal care in participants accentuated the heightened social sensitivity determined by G/G homozygosity, while higher versus lower paternal overprotection lead to distinct levels of physiological arousal particularly in A carriers individuals. These results add to our understanding of the dynamic interplay between genetic susceptibility and early environmental experience in shaping the development of appropriate social sensitivity in males. |
| first_indexed | 2024-10-01T02:31:09Z |
| format | Journal Article |
| id | ntu-10356/87243 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:31:09Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/872432020-03-07T12:10:39Z Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations Truzzi, Anna Poquérusse, Jessie Setoh, Peipei Shinohara, Kazuyuki Bornstein, Marc H. Esposito, Gianluca School of Humanities and Social Sciences Gene–environment Oxytocin Receptor Gene The oxytocinergic system is highly involved in social bonding and early caregiver–infant interactions. Here, we hypothesize that oxytocin receptor (OXTR) gene genotype and parental bonding history interact in influencing social development. To address this question, we assessed adult males’ arousal (heart rate changes) in response to different distress vocalizations (human female, human infant and bonobo). Region rs53576 of the OXTR gene was genotyped from buccal mucosa cell samples, and a self-report Parental Bonding Instrument was used (which provide information about parental care or parental overprotection). A significant gene–environment interaction between OXTR genotype and parenting style was found to influence participants’ social responsivity to female cry vocalizations. Specifically, a history of appropriate paternal care in participants accentuated the heightened social sensitivity determined by G/G homozygosity, while higher versus lower paternal overprotection lead to distinct levels of physiological arousal particularly in A carriers individuals. These results add to our understanding of the dynamic interplay between genetic susceptibility and early environmental experience in shaping the development of appropriate social sensitivity in males. Accepted version 2018-01-24T07:12:03Z 2019-12-06T16:38:00Z 2018-01-24T07:12:03Z 2019-12-06T16:38:00Z 2018 Journal Article Truzzi, A., Poquérusse, J., Setoh, P., Shinohara, K., Bornstein, M. H., & Esposito, G. (2018). Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations. Developmental Psychobiology, in press. 0012-1630 https://hdl.handle.net/10356/87243 http://hdl.handle.net/10220/44341 10.1002/dev.21606 en Developmental Psychobiology © 2018 Wiley Periodicals, Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Developmental Psychobiology, Wiley Periodicals, Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1002/dev.21606]. 29 p. application/pdf |
| spellingShingle | Gene–environment Oxytocin Receptor Gene Truzzi, Anna Poquérusse, Jessie Setoh, Peipei Shinohara, Kazuyuki Bornstein, Marc H. Esposito, Gianluca Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations |
| title | Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations |
| title_full | Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations |
| title_fullStr | Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations |
| title_full_unstemmed | Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations |
| title_short | Oxytocin receptor gene polymorphisms (rs53576) and early paternal care sensitize males to distressing female vocalizations |
| title_sort | oxytocin receptor gene polymorphisms rs53576 and early paternal care sensitize males to distressing female vocalizations |
| topic | Gene–environment Oxytocin Receptor Gene |
| url | https://hdl.handle.net/10356/87243 http://hdl.handle.net/10220/44341 |
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