Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder
Background: Early diagnosis of autism spectrum disorder is critical, because early intensive treatment greatly improves its prognosis. Methods: We review studies that examined vocalizations of infants with autism spectrum disorder and mouse models of autism spectrum disorder as a potential means to...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/87247 http://hdl.handle.net/10220/44378 |
| _version_ | 1811687137228095488 |
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| author | Esposito, Gianluca Hiroi, Noboru Scattoni, Maria Luisa |
| author2 | School of Humanities and Social Sciences |
| author_facet | School of Humanities and Social Sciences Esposito, Gianluca Hiroi, Noboru Scattoni, Maria Luisa |
| author_sort | Esposito, Gianluca |
| collection | NTU |
| description | Background: Early diagnosis of autism spectrum disorder is critical, because early intensive treatment greatly improves its prognosis. Methods: We review studies that examined vocalizations of infants with autism spectrum disorder and mouse models of autism spectrum disorder as a potential means to identify autism spectrum disorder before the symptomatic elements of autism spectrum disorder emerge. We further discuss clinical implications and future research priorities in the field. Results: Atypical early vocal calls (i.e., cry) may represent an early biomarker for autism spectrum disorder (or at least for a subgroup of children with autism spectrum disorder), and thus can assist with early detection. Moreover, cry is likely more than an early biomarker of autism spectrum disorder; it is also an early causative factor in the development of the disorder. Specifically, atypical crying, as recently suggested, might induce a “self-generated environmental factor” that in turn, influences the prognosis of the disorder. Because atypical crying in autism spectrum disorder is difficult to understand, it may have a negative impact on the quality of care by the caregiver (see graphical abstract). Conclusions: Evidence supports the hypothesis that atypical vocalization is an early, functionally integral component of autism spectrum disorder. |
| first_indexed | 2024-10-01T05:11:32Z |
| format | Journal Article |
| id | ntu-10356/87247 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T05:11:32Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/872472020-03-07T12:10:39Z Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder Esposito, Gianluca Hiroi, Noboru Scattoni, Maria Luisa School of Humanities and Social Sciences Autism Spectrum Disorder Cry Background: Early diagnosis of autism spectrum disorder is critical, because early intensive treatment greatly improves its prognosis. Methods: We review studies that examined vocalizations of infants with autism spectrum disorder and mouse models of autism spectrum disorder as a potential means to identify autism spectrum disorder before the symptomatic elements of autism spectrum disorder emerge. We further discuss clinical implications and future research priorities in the field. Results: Atypical early vocal calls (i.e., cry) may represent an early biomarker for autism spectrum disorder (or at least for a subgroup of children with autism spectrum disorder), and thus can assist with early detection. Moreover, cry is likely more than an early biomarker of autism spectrum disorder; it is also an early causative factor in the development of the disorder. Specifically, atypical crying, as recently suggested, might induce a “self-generated environmental factor” that in turn, influences the prognosis of the disorder. Because atypical crying in autism spectrum disorder is difficult to understand, it may have a negative impact on the quality of care by the caregiver (see graphical abstract). Conclusions: Evidence supports the hypothesis that atypical vocalization is an early, functionally integral component of autism spectrum disorder. Published version 2018-02-02T02:22:26Z 2019-12-06T16:38:06Z 2018-02-02T02:22:26Z 2019-12-06T16:38:06Z 2017 Journal Article Esposito, G., Hiroi, N., & Scattoni, M. L. (2017). Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder. International Journal of Neuropsychopharmacology, 20(6), 498-503. 1461-1457 https://hdl.handle.net/10356/87247 http://hdl.handle.net/10220/44378 10.1093/ijnp/pyx014 en International Journal of Neuropsychopharmacology © The Author 2017. Published by Oxford University Press on behalf of CINP. This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com . 6 p. application/pdf |
| spellingShingle | Autism Spectrum Disorder Cry Esposito, Gianluca Hiroi, Noboru Scattoni, Maria Luisa Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder |
| title | Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder |
| title_full | Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder |
| title_fullStr | Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder |
| title_full_unstemmed | Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder |
| title_short | Cry, Baby, Cry: Expression of Distress As a Biomarker and Modulator in Autism Spectrum Disorder |
| title_sort | cry baby cry expression of distress as a biomarker and modulator in autism spectrum disorder |
| topic | Autism Spectrum Disorder Cry |
| url | https://hdl.handle.net/10356/87247 http://hdl.handle.net/10220/44378 |
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