Our Gut Microbiome: The Evolving Inner Self
The “holobiont” concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snaps...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/87346 http://hdl.handle.net/10220/44421 |
| _version_ | 1826124268551798784 |
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| author | Kundu, Parag Blacher, Eran Elinav, Eran Pettersson, Sven |
| author2 | Lee Kong Chian School of Medicine (LKCMedicine) |
| author_facet | Lee Kong Chian School of Medicine (LKCMedicine) Kundu, Parag Blacher, Eran Elinav, Eran Pettersson, Sven |
| author_sort | Kundu, Parag |
| collection | NTU |
| description | The “holobiont” concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being. We discuss the current knowledge of biological symbiosis between the microbiome and its host and portray the challenges in understanding these interactions and their potential effects on human physiology, including microbiome-nervous system inter-relationship and its relevance to human variation and individuality. |
| first_indexed | 2024-10-01T06:17:52Z |
| format | Journal Article |
| id | ntu-10356/87346 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T06:17:52Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/873462020-09-21T11:34:34Z Our Gut Microbiome: The Evolving Inner Self Kundu, Parag Blacher, Eran Elinav, Eran Pettersson, Sven Lee Kong Chian School of Medicine (LKCMedicine) Singapore Centre for Environmental Life Sciences Engineering Microbiome Aging The “holobiont” concept, defined as the collective contribution of the eukaryotic and prokaryotic counterparts to the multicellular organism, introduces a complex definition of individuality enabling a new comprehensive view of human evolution and personalized characteristics. Here, we provide snapshots of the evolving microbial-host associations and relations during distinct milestones across the lifespan of a human being. We discuss the current knowledge of biological symbiosis between the microbiome and its host and portray the challenges in understanding these interactions and their potential effects on human physiology, including microbiome-nervous system inter-relationship and its relevance to human variation and individuality. MOE (Min. of Education, S’pore) Accepted version 2018-02-09T02:28:15Z 2019-12-06T16:40:00Z 2018-02-09T02:28:15Z 2019-12-06T16:40:00Z 2017 Journal Article Kundu, P., Blacher, E., Elinav, E., & Pettersson, S. (2017). Our Gut Microbiome: The Evolving Inner Self. Cell, 171(7), 1481-1493. 0092-8674 https://hdl.handle.net/10356/87346 http://hdl.handle.net/10220/44421 10.1016/j.cell.2017.11.024 en Cell © 2017 Elsevier Inc. This is the author created version of a work that has been peer reviewed and accepted for publication by Cell, Elsevier Inc. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1016/j.cell.2017.11.024]. 34 p. application/pdf |
| spellingShingle | Microbiome Aging Kundu, Parag Blacher, Eran Elinav, Eran Pettersson, Sven Our Gut Microbiome: The Evolving Inner Self |
| title | Our Gut Microbiome: The Evolving Inner Self |
| title_full | Our Gut Microbiome: The Evolving Inner Self |
| title_fullStr | Our Gut Microbiome: The Evolving Inner Self |
| title_full_unstemmed | Our Gut Microbiome: The Evolving Inner Self |
| title_short | Our Gut Microbiome: The Evolving Inner Self |
| title_sort | our gut microbiome the evolving inner self |
| topic | Microbiome Aging |
| url | https://hdl.handle.net/10356/87346 http://hdl.handle.net/10220/44421 |
| work_keys_str_mv | AT kunduparag ourgutmicrobiometheevolvinginnerself AT blachereran ourgutmicrobiometheevolvinginnerself AT elinaveran ourgutmicrobiometheevolvinginnerself AT petterssonsven ourgutmicrobiometheevolvinginnerself |