Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes
The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has sti...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Journal Article |
| Language: | English |
| Published: |
2018
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| Online Access: | https://hdl.handle.net/10356/87405 http://hdl.handle.net/10220/44418 |
| _version_ | 1826130599303184384 |
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| author | Jakobsen, Tim Holm Tolker-Nielsen, Tim Givskov, Michael |
| author2 | Singapore Centre for Environmental Life Sciences Engineering |
| author_facet | Singapore Centre for Environmental Life Sciences Engineering Jakobsen, Tim Holm Tolker-Nielsen, Tim Givskov, Michael |
| author_sort | Jakobsen, Tim Holm |
| collection | NTU |
| description | The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has still not been invented and/or developed any simple, efficient and reliable methods with which to “chemically” eradicate biofilm infections. This underlines the resilience of infective agents present as biofilms and it further emphasizes the insufficiency of today’s approaches used to combat chronic infections. A potential method for biofilm dismantling is chemical interception of regulatory processes that are specifically involved in the biofilm mode of life. In particular, bacterial cell to cell signaling called “Quorum Sensing” together with intracellular signaling by bis-(3′-5′)-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. More recently, regulatory processes governed by two component regulatory systems and small non-coding RNAs have been increasingly investigated. Here, we review novel findings and potentials of using small molecules to target and modulate these regulatory processes in the bacterium Pseudomonas aeruginosa to decrease its pathogenic potential. |
| first_indexed | 2024-10-01T07:58:39Z |
| format | Journal Article |
| id | ntu-10356/87405 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:58:39Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/874052020-09-21T11:35:41Z Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes Jakobsen, Tim Holm Tolker-Nielsen, Tim Givskov, Michael Singapore Centre for Environmental Life Sciences Engineering Quorum Sensing Pseudomonas Aeruginosa The development of effective strategies to combat biofilm infections by means of either mechanical or chemical approaches could dramatically change today’s treatment procedures for the benefit of thousands of patients. Remarkably, considering the increased focus on biofilms in general, there has still not been invented and/or developed any simple, efficient and reliable methods with which to “chemically” eradicate biofilm infections. This underlines the resilience of infective agents present as biofilms and it further emphasizes the insufficiency of today’s approaches used to combat chronic infections. A potential method for biofilm dismantling is chemical interception of regulatory processes that are specifically involved in the biofilm mode of life. In particular, bacterial cell to cell signaling called “Quorum Sensing” together with intracellular signaling by bis-(3′-5′)-cyclic-dimeric guanosine monophosphate (cyclic-di-GMP) have gained a lot of attention over the last two decades. More recently, regulatory processes governed by two component regulatory systems and small non-coding RNAs have been increasingly investigated. Here, we review novel findings and potentials of using small molecules to target and modulate these regulatory processes in the bacterium Pseudomonas aeruginosa to decrease its pathogenic potential. Published version 2018-02-07T04:22:26Z 2019-12-06T16:41:09Z 2018-02-07T04:22:26Z 2019-12-06T16:41:09Z 2017 Journal Article Jakobsen, T. H., Tolker-Nielsen, T., & Givskov, M. (2017). Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes. International Journal of Molecular Sciences, 18(9), 1970-. 1661-6596 https://hdl.handle.net/10356/87405 http://hdl.handle.net/10220/44418 10.3390/ijms18091970 en International Journal of Molecular Sciences © 2017 by The Author(s). Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). 27 p. application/pdf |
| spellingShingle | Quorum Sensing Pseudomonas Aeruginosa Jakobsen, Tim Holm Tolker-Nielsen, Tim Givskov, Michael Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes |
| title | Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes |
| title_full | Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes |
| title_fullStr | Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes |
| title_full_unstemmed | Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes |
| title_short | Bacterial Biofilm Control by Perturbation of Bacterial Signaling Processes |
| title_sort | bacterial biofilm control by perturbation of bacterial signaling processes |
| topic | Quorum Sensing Pseudomonas Aeruginosa |
| url | https://hdl.handle.net/10356/87405 http://hdl.handle.net/10220/44418 |
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