Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Dual blockade of the lipid kinase PIP4Ks and mitotic pathways leads to cancer-selective lethality

Achieving robust cancer-specific lethality is the ultimate clinical goal. Here, we identify a compound with dual-inhibitory properties, named a131, that selectively kills cancer cells, while protecting normal cells. Through an unbiased CETSA screen, we identify the PIP4K lipid kinases as the target...

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Bibliographic Details
Main Authors: Dai, Lingyun, Prabhu, Nayana, Diam, Go Ka, Sobota, Radoslaw, Larsson, Andreas, Nordlund, Pär, McCormick, Frank, Ghosh, Sujoy, Epstein, David M., Dymock, Brian W., Lee, Sang Hyun, Kitagawa, Mayumi, Liao, Pei-Ju, Lee, Kyung Hee, Wong, Jasmine, Shang, See Cheng, Minami, Noriaki, Sampetrean, Oltea, Saya, Hideyuki
Other Authors: School of Biological Sciences
Format: Journal Article
Language:English
Published: 2018
Subjects:
Cancer-selective Lethality
Dual Inhibitory
Online Access:https://hdl.handle.net/10356/87414
http://hdl.handle.net/10220/44426

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