Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation
Biophotonics as a highly interdisciplinary frontier often requires the assistance of optical agents to control the light pathways in cells, tissues and living organisms for specific biomedical applications. Organic semiconducting materials (OSMs) composed of π-conjugated building blocks as the optic...
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/87449 http://hdl.handle.net/10220/47132 |
| _version_ | 1826127435629854720 |
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| author | Li, Jingchao Pu, Kanyi |
| author2 | School of Chemical and Biomedical Engineering |
| author_facet | School of Chemical and Biomedical Engineering Li, Jingchao Pu, Kanyi |
| author_sort | Li, Jingchao |
| collection | NTU |
| description | Biophotonics as a highly interdisciplinary frontier often requires the assistance of optical agents to control the light pathways in cells, tissues and living organisms for specific biomedical applications. Organic semiconducting materials (OSMs) composed of π-conjugated building blocks as the optically active components have recently emerged as a promising category of biophotonic agents. OSMs possess the common features including excellent optical properties, good photostability and biologically benign composition. This review summarizes the recent progress in the development of OSMs based on small-molecule fluorophores, aggregation-induced emission (AIE) dyes and semiconducting oligomer/polymer nanoparticles (SONs/SPNs) for advanced biophotonic applications. OSMs have been exploited as imaging agents to transduce biomolecular interactions into second near-infrared fluorescence, afterglow or photoacoustic signals, enabling deep-tissue ultrasensitive imaging of biological tissues, disease biomarkers and physiological indexes. By finetuning the molecular structures, OSMs can also convert light energy into cytotoxic free radicals or heat, allowing for effective cancer phototherapy. Due to their instance light response and efficient light-harvesting properties, precise regulation of biological activities using OSMs as the remote transducers has been demonstrated for protein ion channels, gene transcription and protein activation. In addition to highlighting OSMs as a multifunctional platform for a wide range of biomedical applications, current challenges and perspectives of OSMs in biophotonics are discussed. |
| first_indexed | 2024-10-01T07:08:50Z |
| format | Journal Article |
| id | ntu-10356/87449 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T07:08:50Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/874492023-12-29T06:51:40Z Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation Li, Jingchao Pu, Kanyi School of Chemical and Biomedical Engineering Organic Semiconducting Materials DRNTU::Engineering::Chemical engineering Biophotonics Biophotonics as a highly interdisciplinary frontier often requires the assistance of optical agents to control the light pathways in cells, tissues and living organisms for specific biomedical applications. Organic semiconducting materials (OSMs) composed of π-conjugated building blocks as the optically active components have recently emerged as a promising category of biophotonic agents. OSMs possess the common features including excellent optical properties, good photostability and biologically benign composition. This review summarizes the recent progress in the development of OSMs based on small-molecule fluorophores, aggregation-induced emission (AIE) dyes and semiconducting oligomer/polymer nanoparticles (SONs/SPNs) for advanced biophotonic applications. OSMs have been exploited as imaging agents to transduce biomolecular interactions into second near-infrared fluorescence, afterglow or photoacoustic signals, enabling deep-tissue ultrasensitive imaging of biological tissues, disease biomarkers and physiological indexes. By finetuning the molecular structures, OSMs can also convert light energy into cytotoxic free radicals or heat, allowing for effective cancer phototherapy. Due to their instance light response and efficient light-harvesting properties, precise regulation of biological activities using OSMs as the remote transducers has been demonstrated for protein ion channels, gene transcription and protein activation. In addition to highlighting OSMs as a multifunctional platform for a wide range of biomedical applications, current challenges and perspectives of OSMs in biophotonics are discussed. MOE (Min. of Education, S’pore) Accepted version 2018-12-20T07:44:02Z 2019-12-06T16:42:08Z 2018-12-20T07:44:02Z 2019-12-06T16:42:08Z 2018 2019 Journal Article Li, J., & Pu, K. (2019). Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation. Chemical Society Reviews. doi:10.1039/C8CS00001H 0306-0012 https://hdl.handle.net/10356/87449 http://hdl.handle.net/10220/47132 10.1039/C8CS00001H 209108 en Chemical Society Reviews © 2018 The Author(s) (Royal Society of Chemistry). This is the author created version of a work that has been peer reviewed and accepted for publication by Chemical Society Reviews, The Author(s) (Royal Society of Chemistry). It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1039/C8CS00001H]. 37 p. application/pdf |
| spellingShingle | Organic Semiconducting Materials DRNTU::Engineering::Chemical engineering Biophotonics Li, Jingchao Pu, Kanyi Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation |
| title | Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation |
| title_full | Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation |
| title_fullStr | Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation |
| title_full_unstemmed | Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation |
| title_short | Development of organic semiconducting materials for deep-tissue optical imaging, phototherapy and photoactivation |
| title_sort | development of organic semiconducting materials for deep tissue optical imaging phototherapy and photoactivation |
| topic | Organic Semiconducting Materials DRNTU::Engineering::Chemical engineering Biophotonics |
| url | https://hdl.handle.net/10356/87449 http://hdl.handle.net/10220/47132 |
| work_keys_str_mv | AT lijingchao developmentoforganicsemiconductingmaterialsfordeeptissueopticalimagingphototherapyandphotoactivation AT pukanyi developmentoforganicsemiconductingmaterialsfordeeptissueopticalimagingphototherapyandphotoactivation |