Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells

Systematic evaluation of CRISPR-Cas systems reveals design principles for genome editing in human cells

Background: While CRISPR-Cas systems hold tremendous potential for engineering the human genome, it is unclear how well each system performs against one another in both non-homologous end joining (NHEJ)-mediated and homology-directed repair (HDR)-mediated genome editing. Results: We systematically c...

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Bibliographic Details
Main Authors: Wang, Yuanming, Liu, Ivy Kaiwen, Sutrisnoh, Norfala-Aliah, Srinivasan, Harini, Zhang, Junyi, Li, Jia, Zhang, Fan, Lalith, Charles Richard John, Xing, Heyun, Shanmugam, Raghuvaran, Foo, Jia Nee, Yeo, Hwee Ting, Ooi, Kean Hean, Bleckwehl, Tore, Par, Rachel Yi Yun, Lee, Shi Mun, Ismail, Nur Nadiah, Sanwari, Nur Aidah, Lee, Vanessa Si Ting, Lew, Jan, Tan, Meng How
Other Authors: School of Chemical and Biomedical Engineering
Format: Journal Article
Language:English
Published: 2018
Subjects:
CRISPR
Genome Editing
Online Access:https://hdl.handle.net/10356/87501
http://hdl.handle.net/10220/45417

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