Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex
G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complex...
| Main Authors: | , , , |
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| Format: | Journal Article |
| Language: | English |
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2018
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| Online Access: | https://hdl.handle.net/10356/87503 http://hdl.handle.net/10220/45427 |
| _version_ | 1811678658444656640 |
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| author | He, Lei Meng, Zhenyu Xu, Dechen Shao, Fangwei |
| author2 | School of Physical and Mathematical Sciences |
| author_facet | School of Physical and Mathematical Sciences He, Lei Meng, Zhenyu Xu, Dechen Shao, Fangwei |
| author_sort | He, Lei |
| collection | NTU |
| description | G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complexes via chelating principles, as a potent therapeutic strategy was surprisingly lack of exploration. Herein, a series of dinuclear platinum complexes, [(Pt(Dip)Cl)2(μ-diamine)](NO3)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), were designed to contain two dual-functional Pt cores connected by an alkyl linkage. Pt3 with nonanediamine linkage optimized the specific binding towards c-myc G-quadruplex via dual functional clamp on GQ as 1) non-covalently π-stacking of aromatic ligands, and 2) two Pt(II) cores covalently chelated to guanines at both 3′- and 5′-ends. |
| first_indexed | 2024-10-01T02:56:46Z |
| format | Journal Article |
| id | ntu-10356/87503 |
| institution | Nanyang Technological University |
| language | English |
| last_indexed | 2024-10-01T02:56:46Z |
| publishDate | 2018 |
| record_format | dspace |
| spelling | ntu-10356/875032023-02-28T19:34:19Z Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex He, Lei Meng, Zhenyu Xu, Dechen Shao, Fangwei School of Physical and Mathematical Sciences G-quadruplexes (GQ) Dinuclear Platinum Complexes G-quadruplexes (GQ) folded by the oncogenic G-rich sequences are the promising targets for developing anticancer therapeutic molecules. However, the current drug development mainly focused on non-covalent dynamic binders to stabilize GQ structures, while the covalent targeting from inorganic complexes via chelating principles, as a potent therapeutic strategy was surprisingly lack of exploration. Herein, a series of dinuclear platinum complexes, [(Pt(Dip)Cl)2(μ-diamine)](NO3)2 (Dip: 4,7-diphenyl-1,10-phenanthroline), were designed to contain two dual-functional Pt cores connected by an alkyl linkage. Pt3 with nonanediamine linkage optimized the specific binding towards c-myc G-quadruplex via dual functional clamp on GQ as 1) non-covalently π-stacking of aromatic ligands, and 2) two Pt(II) cores covalently chelated to guanines at both 3′- and 5′-ends. MOE (Min. of Education, S’pore) Published version 2018-08-02T02:50:26Z 2019-12-06T16:43:17Z 2018-08-02T02:50:26Z 2019-12-06T16:43:17Z 2018 Journal Article He, L., Meng, Z., Xu, D., & Shao, F. (2018). Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex. Scientific Reports, 8(1), 767-. 2045-2322 https://hdl.handle.net/10356/87503 http://hdl.handle.net/10220/45427 10.1038/s41598-017-19095-y en Scientific Reports © 2018 The Author(s) (Nature Publishing Group). This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. 9 p. application/pdf |
| spellingShingle | G-quadruplexes (GQ) Dinuclear Platinum Complexes He, Lei Meng, Zhenyu Xu, Dechen Shao, Fangwei Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex |
| title | Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex |
| title_full | Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex |
| title_fullStr | Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex |
| title_full_unstemmed | Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex |
| title_short | Dual functional dinuclear platinum complex with selective reactivity towards c-myc G-quadruplex |
| title_sort | dual functional dinuclear platinum complex with selective reactivity towards c myc g quadruplex |
| topic | G-quadruplexes (GQ) Dinuclear Platinum Complexes |
| url | https://hdl.handle.net/10356/87503 http://hdl.handle.net/10220/45427 |
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